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A short-term, multicenter, randomized double-blind dose titration study of the efficacy and anticholinergic side effects of transdermal compared to immediate release oral oxybutynin treatment of patients with urge urinary incontinence.

Author: , DaughertyC A, DavilaG W, SandersS W

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Transdermal oxybutynin was found to be as effective as oral oxybutynin in treating urge urinary incontinence, but with a significantly improved side effect profile. Both treatments resulted in a decrease in daily incontinent episodes (66% for transdermal and 72% for oral). Dry mouth occurred in significantly fewer patients in the transdermal group (38%) compared to the oral group (94%).
Paper Details　
Original Abstract of the Article :
PURPOSE: We compared the short-term efficacy, safety and tolerability of transdermal versus oral oxybutynin in adults with urge urinary incontinence. MATERIALS AND METHODS: Volunteers with detrusor instability currently responding to oral immediate release oxybutynin were enrolled in our study. Tho...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11435842

データ提供：米国国立医学図書館（NLM）

Transdermal vs. Oral Oxybutynin for Urge Urinary Incontinence: A Comfortable Journey Through the Desert of Bladder Control

Urge urinary incontinence, a condition that can lead to frequent and uncontrollable urination, can feel like navigating a desert of bladder dysfunction. This study compares the efficacy and side effects of two different oxybutynin formulations, transdermal and oral, for treating urge urinary incontinence. Researchers are like desert engineers, seeking to find the most comfortable and efficient way to manage this common condition.

Two Pathways to Relief: Finding the Right Oasis for Bladder Control

This study found that transdermal oxybutynin was as effective as oral oxybutynin in reducing urge urinary incontinence episodes but with significantly fewer anticholinergic side effects. It's like choosing a smooth and paved path through the desert, offering a more comfortable journey with fewer bumps along the way. The study highlights the potential benefits of transdermal delivery, which allows for consistent medication levels and reduced side effects.

Health Implications and Life Applications

This study suggests that transdermal oxybutynin may be a preferred option for individuals with urge urinary incontinence, offering a more comfortable and convenient way to manage symptoms. For those struggling with bladder control, discussing treatment options with their healthcare providers and exploring different formulations can help find the most effective and tolerable approach. It's like choosing the right camel for the journey, ensuring a smooth and enjoyable passage through the desert of bladder control.

Dr.Camel's Conclusion

This research suggests that transdermal oxybutynin may be a more comfortable and convenient option for managing urge urinary incontinence. By understanding the nuances of different medication delivery methods, we can find the right oasis of relief for each individual, making the journey through the desert of bladder dysfunction more enjoyable and manageable.

Date :
  1. Date Completed 2001-08-09
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

11435842

DOI: Digital Object Identifier

S0022-5347(05)66095-8

Related Literature

Article Analysis
・Side Effects of oxybutynin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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