A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis.

Author: ChernW, FurstK, LevyS

Paper Details 
Original Abstract of the Article :
BACKGROUND: Systemic absorption of topical fluorouracil, although usually low, may vary as a result of the specific skin disease, product formulation, and other factors. OBJECTIVE: The present study was conducted to determine the pharmacokinetic profile and tolerability of a new topical 0.5% fluoro...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/s0149-2918(01)80078-3

データ提供:米国国立医学図書館(NLM)

Fluorouracil: A Topical Treatment for Actinic Keratosis

Actinic keratosis (AK), a precancerous skin condition, can be a concerning desert of potential health risks. This research, like a caravan of scientists exploring this challenging landscape, investigates the pharmacokinetic profile and tolerability of two topical fluorouracil formulations: 0.5% and 5%. The study, an open-label, parallel-group study, compared the systemic absorption and side effects of these formulations in patients with AK. The results, like a well-mapped oasis, revealed that the 0.5% formulation had minimal systemic absorption and was well tolerated, while the 5% formulation had higher systemic absorption and greater side effects. This study provides valuable insights for optimizing the use of topical fluorouracil in treating AK.

Fluorouracil: Navigating the Desert of Skin Cancer

This study, like a compass guiding us through the desert of skin cancer prevention, highlights the importance of selecting the appropriate formulation of topical fluorouracil for treating AK. The findings suggest that the 0.5% formulation, with its minimal systemic absorption and favorable tolerability profile, may be a preferable option for many patients. This research, like a well-placed oasis, offers a promising approach to managing AK while minimizing potential side effects.

Harnessing the Power of Fluorouracil

The results of this study, like a beacon in the desert, underscore the importance of individualized treatment approaches for AK. While topical fluorouracil can be an effective treatment option, careful consideration of the formulation and potential side effects is crucial. Remember, consulting with a dermatologist is essential for personalized recommendations and to ensure safe and effective use of this medication.

Dr.Camel's Conclusion

Actinic keratosis, like a harsh desert, can pose a threat to skin health. This study, like a caravan of researchers seeking solutions in this arid landscape, investigates the effectiveness of topical fluorouracil. The findings provide valuable insights for optimizing treatment, reminding us that careful selection of the appropriate formulation can be a key factor in navigating the challenges of AK.

Date :
  1. Date Completed 2001-12-04
  2. Date Revised 2019-09-21
Further Info :

Pubmed ID

11440290

DOI: Digital Object Identifier

10.1016/s0149-2918(01)80078-3

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.