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Switch-over from tolcapone to entacapone in severe Parkinson's disease patients.

Author: BonanniL, Di IorioA, IaconoD, OnofrjM, ThomasA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study examined the effectiveness and side effects of tolcapone and entacapone, two drugs used to treat Parkinson's disease, in patients already taking L-DOPA. Both drugs significantly reduced the daily dose of L-DOPA needed and increased "on" time while decreasing "off" time, indicating improved control of Parkinson's symptoms. However, side effects such as diarrhea, liver enzyme elevation, and dyskinesias were observed.
Paper Details　
Original Abstract of the Article :
Forty patients affected by severe Parkinson's disease (PD) were treated with tolcapone as an adjunctive therapy to L-DOPA, for 3-7 months, until this drug was discontinued because of side-effects (2 diarrhoea, one of them with orthostatic hypotension, 2 increments of liver enzymes) or because of man...See full text at original site
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引用元：
https://doi.org/10.1159/000050749

データ提供：米国国立医学図書館（NLM）

Switching Medications for Parkinson's Disease: A Case for Individualized Care

Parkinson's disease (PD) is a neurodegenerative disorder that can significantly impact mobility and quality of life. This study examines the effectiveness of switching from tolcapone to entacapone in patients with severe PD. The researchers evaluated the impact of these medications on L-DOPA dosage, 'on' time, and 'off' time, seeking to find a safe and effective treatment approach for managing severe PD symptoms.

Finding the Right Fit: A Personalized Approach to PD Treatment

The study highlights the importance of individualized treatment approaches for PD, acknowledging that different patients may respond differently to various medications. While both tolcapone and entacapone showed improvements in 'on' time and reductions in 'off' time, some patients experienced side effects, necessitating medication switches. This reinforces the need for close monitoring and adjustments based on individual patient responses.

Living with Parkinson's Disease: A Collaborative Journey

Managing PD is a collaborative journey between patient and healthcare provider. It's crucial to have open communication about symptoms, medication effects, and any potential concerns. Remember, there is no one-size-fits-all solution for PD, and finding the right treatment plan involves a personalized approach tailored to your unique needs.

Dr. Camel's Conclusion

This study reinforces the importance of individualized treatment approaches for PD, acknowledging the diverse responses to medications. It emphasizes the need for ongoing monitoring, communication with your healthcare provider, and a willingness to adjust treatment plans as needed. Remember, managing PD is a journey, and finding the right path requires collaboration, patience, and a personalized approach.

Date :
  1. Date Completed 2001-09-06
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

11455177

DOI: Digital Object Identifier

10.1159/000050749

SNS
PICO Info
in preparation
Languages

English

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