Serious adverse events associated with yellow fever 17DD vaccine in Brazil: a report of two cases.

Author: , AlmeidaL M, AlvesV A, AndradeL D, BarrosV L, CoimbraT L, CostaZ G, CruzA C, FroguasG B, GallerR, LacavaE, LavalC, LunaE J, MonathT P, OlivaO F, PapaiordanouC M, PapaiordanouP M, RoccoI M, RodiguesS G, RosaE S, SantosC L, SantosR T, SatoH K, SilvaL J, VasconcelosP F, VilelaM F

Paper Details 
Original Abstract of the Article :
BACKGROUND: The yellow fever vaccine is regarded as one of the safest attenuated virus vaccines, with few side-effects or adverse events. We report the occurrence of two fatal cases of haemorrhagic fever associated with yellow fever 17DD substrain vaccine in Brazil. METHODS: We obtained epidemiolog...See full text at original site
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引用元:
https://doi.org/10.1016/s0140-6736(01)05326-0

データ提供:米国国立医学図書館(NLM)

A Rare and Unexpected Turn of Events: Yellow Fever Vaccine Complications

Vaccines are considered a cornerstone of modern medicine, protecting individuals from deadly diseases. However, even the safest vaccines can occasionally lead to unexpected complications. This study reports two fatal cases of hemorrhagic fever associated with the yellow fever 17DD substrain vaccine in Brazil. The researchers meticulously investigated these cases, seeking to understand the factors that contributed to these rare and tragic outcomes.

Unraveling the Mystery of Vaccine Complications

The researchers meticulously examined the epidemiological, serological, virological, pathological, and molecular biological data from the two cases. They confirmed that the yellow fever virus recovered from the patients was identical to the 17D genomic sequences. However, they also noted that the patients exhibited severe and atypical symptoms, suggesting an idiosyncratic reaction to the vaccine. It's like a desert mirage, appearing as a potential oasis but ultimately revealing a different and unexpected reality.

The Need for Vigilance and Continued Research

This study highlights the importance of ongoing vigilance in monitoring vaccine safety and the potential for rare but serious complications. The researchers emphasize the need for further research to understand the factors that contribute to these unexpected reactions. It's a reminder that even the most well-established medical practices can be subject to unforeseen challenges, requiring ongoing investigation and a commitment to ensuring patient safety. Just as a seasoned desert explorer constantly seeks new knowledge and adapts to the changing landscape, we must remain vigilant in our pursuit of safer and more effective vaccines.

Dr.Camel's Conclusion

This research underscores the importance of vigilance and ongoing research in vaccine safety. It's a stark reminder that even the most effective medical interventions can occasionally lead to unexpected complications. We must continue to explore the desert of vaccine research to identify and address these rare but significant challenges.

Date :
  1. Date Completed 2001-08-09
  2. Date Revised 2019-06-11
Further Info :

Pubmed ID

11463409

DOI: Digital Object Identifier

10.1016/s0140-6736(01)05326-0

Related Literature

SNS
PICO Info
in preparation
Languages

English

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