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Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: A multicenter, randomized, placebo-controlled trial.

Author: , BarbarashR A, BergJ E, GunnillL B, JonesT M, JorizzoJ L, KatzD H, KhalilM H, MikolichD J, MorrowP R, PopeL E, RuoffG E, SacksS L, ThistedR A, YakatanG J

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Docosanol 10% cream applied 5 times daily is safe and effective in the treatment of recurrent herpes simplex labialis, with a median healing time of 4.1 days, 18 hours shorter than placebo.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Recurrent herpes simplex labialis (HSL) occurs in 20% to 40% of the US population. Although the disease is self-limiting in persons with a healthy immune response, patients seek treatment because of the discomfort and visibility of a recurrent lesion. OBJECTIVE: Our purpose was to deter...See full text at original site
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引用元：
https://doi.org/10.1067/mjd.2001.116215

データ提供：米国国立医学図書館（NLM）

A Balm for the Blisters: Docosanol 10% Cream for Herpes Simplex Labialis

Herpes simplex labialis (HSL), commonly known as cold sores, is a viral infection that can cause painful and unsightly blisters on the lips. This study investigates the effectiveness of topical docosanol 10% cream in treating episodes of acute HSL. The researchers conducted two identical double-blind, placebo-controlled trials to compare the efficacy of docosanol with a placebo.

A Promising Treatment: Docosanol's Effectiveness

The study found that docosanol 10% cream significantly reduced the time to healing for HSL episodes compared with the placebo. It also demonstrated a faster reduction in pain and other symptoms, including itching, burning, and tingling.

A New Frontier in Treatment: Docosanol's Potential

This study highlights the potential of docosanol 10% cream as an effective treatment for HSL, offering a safe and well-tolerated alternative to existing therapies. It encourages further research to explore its role in managing recurrent HSL and to investigate its long-term efficacy and safety.

Dr. Camel's Conclusion

This study, like a camel caravan discovering a refreshing oasis in the desert, provides evidence of the effectiveness of docosanol 10% cream in treating herpes simplex labialis. It offers a promising treatment option for those seeking relief from this common and often bothersome condition. The research encourages continued investigation into the use of docosanol for HSL and its potential to improve patient outcomes.

Date :
  1. Date Completed 2001-08-23
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

11464183

DOI: Digital Object Identifier

10.1067/mjd.2001.116215

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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