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A placebo-controlled, crossover trial of granisetron in SRI-induced sexual dysfunction.

Author: KeckP E, NelsonE B, ShahV N, WelgeJ A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Many people taking serotonin reuptake inhibitors (SRIs) experience sexual side effects, which are thought to be caused by direct serotonin activity. This study investigates the effect of granisetron, a serotonin antagonist, on sexual dysfunction in patients taking SRIs. The study randomly assigned patients to receive either granisetron or placebo in a crossover design.
Paper Details　
Original Abstract of the Article :
Sexual side effects are commonly associated with serotonin reuptake inhibitor (SRI) therapy. The mechanism underlying SRI-induced sexual dysfunction has been hypothesized to be mediated by direct serotonergic effects. Evidence from open-label reports suggests that cyproheptadine, nefazodone, mirtaza...See full text at original site
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引用元：
https://doi.org/10.4088/jcp.v62n0611

データ提供：米国国立医学図書館（NLM）

Tackling the Desert of Sexual Dysfunction: A New Approach

Sexual dysfunction can be a distressing side effect of serotonin reuptake inhibitor (SRI) therapy. This research explores the potential of granisetron, a serotonin-3 antagonist, as a remedy for SRI-induced sexual dysfunction.

Granisetron's Potential to Relieve Sexual Side Effects

The study investigates the effectiveness of granisetron compared to placebo in patients experiencing sexual dysfunction during SRI treatment. The results suggest that granisetron may be a promising option for alleviating these side effects.

Navigating the Side Effects of SRI Therapy

This research offers a potential solution for patients experiencing sexual side effects associated with SRI therapy. By exploring alternative treatments that target specific serotonin receptors, we can improve the overall quality of life for individuals taking these medications.

Dr.Camel's Conclusion

This study provides a glimmer of hope for patients struggling with SRI-induced sexual dysfunction. By exploring the potential of granisetron, we can potentially alleviate this distressing side effect and improve the overall treatment experience. This research emphasizes the importance of personalized medicine, tailoring treatment approaches to individual patient needs and addressing potential side effects effectively.

Date :
  1. Date Completed 2001-08-02
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

11465525

DOI: Digital Object Identifier

10.4088/jcp.v62n0611

Related Literature

Article Analysis
・Side Effects of granisetron
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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