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Open-label dose-titration safety and efficacy study of tizanidine hydrochloride in the treatment of spasticity associated with chronic stroke.

Author: DromerickA, GelberD A, GoodD C, RichardsonM, SergayS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the safety and efficacy of tizanidine, a centrally acting alpha(2)-adrenergic agonist, in the treatment of stroke-related spasticity.
Paper Details　
Original Abstract of the Article :
Spasticity is a frequently observed motor impairment that develops after stroke; it can cause pain and disability in those affected. The objective of the present study was to evaluate the safety and efficacy of tizanidine, a centrally acting alpha(2)-adrenergic agonist, in the treatment of stroke-re...See full text at original site
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引用元：
https://doi.org/10.1161/01.str.32.8.1841

データ提供：米国国立医学図書館（NLM）

Open-label Dose-Titration Safety and Efficacy Study of Tizanidine Hydrochloride in the Treatment of Spasticity Associated with Chronic Stroke

The journey of recovery from a stroke can be long and challenging. One common complication is spasticity, which can cause pain and disability. This study investigates the safety and efficacy of tizanidine, a medication used to treat stroke-related spasticity.

The researchers conducted an open-label dose-titration study to evaluate the effectiveness of tizanidine in patients with stroke-related spasticity. The study found that tizanidine was generally well-tolerated and effective in reducing spasticity. This research provides valuable insights into the potential of tizanidine as a treatment option for stroke-related spasticity.

A Promising Treatment Option for Stroke-Related Spasticity

This study suggests that tizanidine may be a promising treatment option for stroke-related spasticity. The study found that tizanidine was effective in reducing spasticity and was generally well-tolerated. This research offers hope for patients struggling with spasticity after a stroke, providing a potential avenue for improved mobility and quality of life.

Understanding the Potential Benefits and Risks of Tizanidine

While this study suggests that tizanidine can be a valuable treatment option, it is important to carefully consider the potential benefits and risks. As with any medication, tizanidine may have side effects. It is essential to consult with a healthcare professional to determine if tizanidine is the right treatment option.

Dr.Camel's Conclusion

Just as a camel navigates the desert landscape, doctors must be able to navigate the complex world of stroke rehabilitation. This study offers a valuable resource for understanding the potential benefits and risks of tizanidine for stroke-related spasticity, highlighting the importance of individualized care and careful consideration of treatment options.

Date :
  1. Date Completed 2001-08-30
  2. Date Revised 2019-07-27
Further Info :

Pubmed ID

11486114

DOI: Digital Object Identifier

10.1161/01.str.32.8.1841

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・Side Effects of tizanidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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