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Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection.

Author: , AlbrechtM A, BoschR J, DehlingerM, EronJ, HammerS M, KatzensteinD A, KesslerH, LiouS H, ParaM F, ValdezH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

The study investigated the effectiveness of various antiretroviral treatment regimens for patients with HIV viremia despite nucleoside analogue treatment. Regimens combining two nucleoside analogues with either nelfinavir, efavirenz, or both were evaluated.
Paper Details　
Original Abstract of the Article :
The optimal antiretroviral treatment for patients who have human immunodeficiency virus (HIV) viremia despite treatment with nucleoside reverse-transcriptase inhibitors (nucleoside analogues) remains uncertain. We studied treatment with regimens that combined two nucleoside analogues, at least one o...See full text at original site
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引用元：
https://doi.org/10.1056/NEJM200108093450602

データ提供：米国国立医学図書館（NLM）

Finding the Right Antiretroviral Regimen: A Challenge for HIV Treatment

The development of [effective antiretroviral therapy] is a crucial aspect of [HIV management]. This research investigates the efficacy of different [antiretroviral regimens] in patients who experienced [treatment failure] with [nucleoside reverse-transcriptase inhibitors (nucleoside analogues)]. The researchers studied the effects of [regimens combining two nucleoside analogues with nelfinavir, efavirenz, or both] on [HIV viremia]. The study's findings provide valuable insights into the [optimal treatment strategies] for [HIV-infected patients] who have experienced [treatment failure] with [nucleoside analogues].

Optimizing Antiretroviral Therapy for HIV Treatment Failure

The study's results highlight the importance of [tailoring antiretroviral regimens] to the individual patient's needs and [treatment history]. The researchers' findings suggest that [combining different drug classes] can be effective in [suppressing HIV viremia] in patients who have experienced [treatment failure] with [nucleoside analogues]. The study's findings provide valuable guidance for clinicians in selecting the [most appropriate antiretroviral regimen] for these patients.

The Importance of Personalized HIV Treatment

This research underscores the importance of [individualized care] in [HIV management]. The study's findings demonstrate that [different antiretroviral regimens] can have varying levels of efficacy in [patients who have experienced treatment failure]. The need for [personalized treatment strategies] is crucial for optimizing outcomes and improving the health and well-being of [HIV-infected patients]. Continued research is needed to further refine the use of [different antiretroviral regimens] and develop new therapies that can effectively combat [HIV infection].

Dr.Camel's Conclusion

Just like the desert landscape varies from oasis to barren wasteland, so too does the HIV virus respond differently to various treatment strategies. This research emphasizes the need for a personalized approach to HIV treatment, ensuring that each patient receives the most effective therapy for their individual needs.

Date :
  1. Date Completed 2001-08-16
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

11496850

DOI: Digital Object Identifier

10.1056/NEJM200108093450602

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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