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Topiramate on ictal seizure semiology: a quantitative, randomized, low and medium dose-controlled study.

Author: PauliE, StefanH, WangY, ZhouD

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Topiramate (TPM) had an early dose-dependent effect on ictal seizures, with more significant reductions in the duration, intensity, and frequency of ictal signs like hypermotoric movements, fumbling, and vocalization in the medium dosage group (200 mg daily).
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Intensive and quantitative evaluation of the severity and frequency of seizures and ictal signs during topiramate (TPM) treatment. METHODS: Twenty patients with refractory partial seizures undergoing presurgical evaluation were randomized into a low dosage (100 mg daily) and a parallel m...See full text at original site
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引用元：
https://doi.org/10.1016/s0920-1211(01)00283-2

データ提供：米国国立医学図書館（NLM）

Topiramate: A Dose-Dependent Effect on Seizures

Topiramate is an anticonvulsant medication often used to treat epilepsy. This study focuses on the effect of topiramate on ictal seizure semiology, or the outward manifestations of seizures, in individuals with refractory partial seizures. This research delves into the nuances of topiramate's effects on seizures, providing insights into its potential benefits and optimal dosing.

Topiramate's Dose-Dependent Impact

The research reveals that topiramate demonstrates a dose-dependent effect on ictal seizures. The study found that the higher dosage group experienced a more significant reduction in seizure frequency, duration, and intensity. This finding is important for clinicians to consider when prescribing topiramate for their patients with epilepsy.

Navigating the Desert of Epilepsy Treatment

Topiramate's dose-dependent effect on ictal seizures emphasizes the importance of individualized treatment plans for epilepsy. This research is like a compass, guiding us towards a more tailored approach to managing epilepsy.

Dr.Camel's Conclusion

Topiramate's dose-dependent impact on seizures is a valuable insight into the complexities of epilepsy treatment. This research is a beacon of hope in the desert of epilepsy research.

Date :
  1. Date Completed 2001-12-04
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

11518628

DOI: Digital Object Identifier

10.1016/s0920-1211(01)00283-2

Related Literature

Article Analysis
・Effective treatment of seizures
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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