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A review of rosiglitazone in type 2 diabetes mellitus.

Author: TravagliniM T, WernerA L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Rosiglitazone maleate, a thiazolidinedione, improved insulin sensitivity in muscle and adipose tissue, potentially sustaining or improving beta-cell function. The drug reduced fasting plasma glucose, glycosylated hemoglobin, insulin, and C-peptide, and significantly reduced glycosylated hemoglobin by 1.5% compared with placebo.
Paper Details　
Original Abstract of the Article :
The thiazolidinedione rosiglitazone maleate works primarily to improve insulin sensitivity in muscle and adipose tissue. It may have additional pharmacologic effects, however, as its main target is peroxisome proliferator-activated receptor-gamma. Data using the homeostasis model assessment and proi...See full text at original site
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引用元：
https://doi.org/10.1592/phco.21.13.1082.34615

データ提供：米国国立医学図書館（NLM）

Rosiglitazone for Type 2 Diabetes

Type 2 diabetes is a condition that affects how your body uses sugar. It can lead to high blood sugar levels, which can cause various health problems. This study focuses on a specific medication called rosiglitazone, which is used to treat type 2 diabetes.

Improving Insulin Sensitivity

Rosiglitazone is a type of medication known as a thiazolidinedione. It primarily works by improving insulin sensitivity in muscle and fat tissue. Think of insulin like a key that unlocks your body's cells to let sugar in. Rosiglitazone makes the key work better, allowing more sugar to enter the cells and lower blood sugar levels.

Benefits and Side Effects of Rosiglitazone

In clinical trials, rosiglitazone has shown promising results. It significantly reduced blood sugar levels and improved glycemic control in patients with type 2 diabetes, either alone or in combination with other medications. While generally well-tolerated, it's important to be aware of potential side effects like edema (swelling), anemia, and weight gain. As with any medication, it's crucial to have open and honest conversations with your doctor about the benefits and risks.

Dr. Camel's Conclusion

This research highlights the potential of rosiglitazone as a therapeutic option for type 2 diabetes. Its ability to improve insulin sensitivity and blood sugar control offers hope for patients seeking better management of their condition. Like a camel traversing a vast desert, finding the right balance of medication and lifestyle choices is crucial for managing diabetes effectively. Remember, a little patience and understanding can go a long way in managing this complex condition.

Date :
  1. Date Completed 2002-02-19
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

11560198

DOI: Digital Object Identifier

10.1592/phco.21.13.1082.34615

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in preparation
Languages

English

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