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Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor.
Author: MeltzerH Y, RauserL, RothB L, SavageJ E
Original Abstract of the Article :
Atypical antipsychotic drugs, which are distinguished from typical antipsychotic drugs by a lower incidence of extra-pyramidal side effects and less propensity to elevate serum prolactin levels (e.g., clozapine, olanzapine, risperidone, quetiapine, ziprasidone), have become the most widely used trea...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/11561066
データ提供:米国国立医学図書館(NLM)
Antipsychotic Drugs: Unraveling the Mystery of Atypicality
The world of antipsychotic drugs is a complex one, with many different types, each with its unique mechanism of action. This research delves into the intriguing world of [antipsychotic drugs], exploring the differences between 'typical' and 'atypical' drugs and the role of a specific serotonin receptor, the [5-HT2C receptor], in their effectiveness.
The 5-HT2C Receptor: A Key Player in Antipsychotic Action
The researchers investigated the actions of a wide range of antipsychotic drugs on the [5-HT2C receptor]. They discovered that both typical and atypical antipsychotic drugs can exhibit 'inverse agonist' effects at this receptor, meaning they can dampen its activity. However, they found no clear connection between this inverse agonist action and a drug's atypicality, challenging previous ideas about what distinguishes atypical drugs from typical ones.
Navigating the Antipsychotic Desert: A Deeper Understanding
This research provides valuable insights into the complex interplay between antipsychotic drugs and the [5-HT2C receptor]. The findings suggest that the [5-HT2C receptor] might play a more nuanced role in the action of antipsychotic drugs than previously thought. This understanding could lead to the development of more effective and targeted antipsychotic medications with fewer side effects.
Dr.Camel's Conclusion
Like a desert explorer navigating an uncharted territory, this study sheds light on the complex world of antipsychotic drugs. The findings challenge our understanding of how these drugs work, revealing a more intricate dance between antipsychotic drugs and the 5-HT2C receptor. This newfound knowledge could pave the way for developing more effective and personalized treatments for mental health conditions.
Date :
- Date Completed 2001-10-18
- Date Revised 2010-11-18
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English
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