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Structural basis for the interference between nicorandil and sulfonylurea action.
Author: AshcroftF M, GribbleF M, ReimannF
Original Abstract of the Article :
Nicorandil is a new antianginal agent that potentially may be used to treat the cardiovascular side effects of diabetes. It is both a nitric oxide donor and an opener of ATP-sensitive K(+) (K(ATP)) channels in muscle and thereby causes vasodilation of the coronary vasculature. The aim of this study ...See full text at original site
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引用元：
https://doi.org/10.2337/diabetes.50.10.2253
データ提供：米国国立医学図書館（NLM）
Understanding the Interactions of Nicorandil and Sulfonylureas
The desert of drug interactions can be treacherous, with unexpected consequences lurking around every corner. This study, published in the journal British Journal of Pharmacology, investigates the potential for interactions between nicorandil, an antianginal agent, and sulfonylureas, a class of hypoglycemic drugs. The researchers, like skilled cartographers, mapped the domains of the KATP channel involved in the actions of these drugs, revealing potential for overlapping targets and possible drug interactions. This research highlights the importance of understanding the mechanisms of action of different drugs and the potential for unforeseen interactions.
Navigating the Desert of Drug Interactions
This study, like a well-equipped caravan traversing a vast desert, provides valuable insights into the potential for interactions between nicorandil and sulfonylureas. The findings demonstrate that these drugs share common targets, suggesting the possibility of adverse effects when used together. This research emphasizes the importance of careful consideration of drug interactions and the need for vigilant monitoring of patients taking multiple medications.
A Reminder of the Importance of Drug Safety
This study serves as a reminder of the importance of drug safety and the potential for unforeseen interactions. It's like navigating a desert with a compass – we need to carefully consider the mechanisms of action of different drugs and the potential for overlapping targets, ensuring the safe and effective use of medication.
Dr.Camel's Conclusion
This study highlights the potential for interactions between nicorandil and sulfonylureas, emphasizing the importance of understanding drug interactions and the need for careful monitoring of patients taking multiple medications. It's like navigating a vast and unforgiving desert, where a single misstep can have significant consequences. By understanding the complexities of drug interactions, we can ensure patient safety and optimize the effectiveness of treatment.
Date :
- Date Completed 2001-10-25
- Date Revised 2019-05-15
Further Info :
Related Literature
English
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