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The ever-emerging anti-inflammatories. Have there been any real advances?

Author: RainsfordK D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Gastrointestinal adverse drug reactions (ADRs) are a significant concern with NSAIDs. This abstract discusses the development of COX-2 selective drugs, their potential benefits and drawbacks, and alternative strategies for developing safer NSAIDs.
Paper Details　
Original Abstract of the Article :
Gastrointestinal (GI) Adverse Drug Reactions (ADRs) from the NSAIDs are a major cause of morbidity and mortality in arthritic patients taking these drugs. The recent much heralded development of COX-2 selective drugs (celecoxib, rofecoxib), the objective of which has been to spare inhibition of the ...See full text at original site
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引用元：
https://doi.org/10.1016/s0928-4257(01)00004-3

データ提供：米国国立医学図書館（NLM）

The Ever-Emerging Anti-Inflammatories: A Quest for Safer NSAIDs

This research delves into the fascinating world of pharmacology, specifically exploring the ongoing quest for safer nonsteroidal anti-inflammatory drugs (NSAIDs). Much like a camel searching for a safe and reliable water source in the desert, researchers are continually seeking to refine NSAID formulations to minimize side effects. The authors discuss the development of COX-2 selective drugs, nitric oxide-donating NSAIDs, and mixed COX-5 lipoxygenase (LOX) inhibitors, highlighting the ongoing search for NSAIDs with a better safety profile. This research provides valuable insights into the challenges and opportunities in developing safer anti-inflammatory medications.

The Quest for Safer NSAIDs Continues

This review highlights the ongoing challenge of developing NSAIDs with reduced gastrointestinal side effects. While COX-2 selective drugs initially showed promise, concerns have arisen regarding their potential cardiovascular risks. The authors emphasize the need for continued research to identify safer NSAIDs that effectively manage pain and inflammation without causing undue harm.

Navigating the Desert of Side Effects

NSAIDs are a valuable tool in managing pain and inflammation, but they can sometimes come with unwanted side effects. This research underscores the importance of understanding the different types of NSAIDs and their potential risks. Just as a camel navigates the desert by carefully selecting its path, individuals taking NSAIDs can work with their healthcare providers to make informed choices about the most appropriate medications. This research provides valuable insights into the ongoing efforts to develop safer NSAIDs, offering hope for individuals seeking pain relief without excessive side effects.

Dr. Camel's Conclusion

The quest for safer NSAIDs continues, with ongoing research exploring new approaches and formulations. By understanding the challenges and opportunities in this field, we can work towards developing anti-inflammatory medications that effectively manage pain and inflammation without compromising patient safety.

Date :
  1. Date Completed 2002-02-19
  2. Date Revised 2019-11-05
Further Info :

Pubmed ID

11595413

DOI: Digital Object Identifier

10.1016/s0928-4257(01)00004-3

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