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Acute doses of d-amphetamine and bupropion increase cigarette smoking.

Author: CousinsM S, StamatH M, de WitH

Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Bupropion is a drug used for smoking cessation. This study investigated the acute effects of bupropion on smoking behavior. The researchers hypothesized that bupropion, similar to amphetamine, would increase smoking when administered acutely.
Paper Details　
Original Abstract of the Article :
Bupropion is used clinically as a treatment for smoking cessation, but the processes by which it reduces smoking are poorly understood. Bupropion shares some neurochemical actions and behavioral effects with the psychostimulant amphetamine, and it has been shown that amphetamine increases smoking wh...See full text at original site
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引用元：
https://doi.org/10.1007/s002130100802

データ提供：米国国立医学図書館（NLM）

Bupropion and Amphetamine: A Tale of Two Stimulants and Smoking

In the ever-evolving landscape of smoking cessation treatments, bupropion stands as a prominent player. However, the precise mechanisms by which it reduces smoking remain a subject of intense scientific inquiry. This study delves into the intriguing relationship between bupropion and amphetamine, two psychostimulants that share certain neurochemical actions and behavioral effects. The authors investigated the effects of single doses of bupropion on cigarette smoking, hypothesizing that, based on its similarities to amphetamine, acute bupropion administration might also lead to an increase in smoking.

A Dose of Reality: Bupropion's Complex Effects

The research revealed that while amphetamine has been shown to increase smoking when administered acutely, the effects of bupropion on smoking are more nuanced. The study found that single doses of bupropion did not increase smoking. This finding adds complexity to the understanding of bupropion's mechanism of action in smoking cessation, suggesting that its effects may be more subtle and potentially mediated by mechanisms other than those shared with amphetamine.

Navigating the Smokescreen: A Balancing Act

The study's findings underscore the complexity of smoking cessation and the need for a multifaceted approach to treating tobacco dependence. While bupropion's impact on smoking may not be as direct as initially anticipated, it remains a valuable tool in the fight against nicotine addiction. This research highlights the importance of carefully evaluating the effects of medications on individual patients and tailoring treatment strategies accordingly.

Dr.Camel's Conclusion

This research sheds light on the intricate relationship between bupropion, amphetamine, and smoking behavior. Just as a desert traveler must navigate a complex landscape to find an oasis, researchers continue to explore the complex pathways involved in smoking cessation. The findings suggest that bupropion's effects on smoking may be more intricate than previously thought, reminding us that a comprehensive understanding of these mechanisms is essential for developing effective smoking cessation strategies.

Date :
  1. Date Completed 2001-12-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11605079

DOI: Digital Object Identifier

10.1007/s002130100802

SNS
PICO Info
in preparation
Languages

English

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