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Induction chemotherapy followed by concomitant chemoradiation therapy in advanced head and neck cancer: a phase II study for organ-sparing purposes evaluating feasibility, effectiveness and toxicity.

Author: AmichettiMaurizio, AstaraGiorgio, CamboniPaolo, FerreliLuca, GramignanoGiulia, LussoMaria Rita, MaccioAntonio, MadedduClelia, MantovaniGiovanni, MassaElena, MocciMiria, MuduM Caterina, MulasCarlo, MuraLoredana, MuraManfredi, MurgiaViviana, ProtoErnesto, ToreGiorgio

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 26 patients with stage IV head and neck cancer found that a sequential induction chemotherapy and chemoradiotherapy program was moderately active but significantly toxic. The overall response rate was 52.6% for induction chemotherapy and 58.3% for chemoradiotherapy. The median overall survival time was 9 months. The treatment was associated with significant toxicity, mainly mucositis and neutropenia/thrombocytopenia.
Paper Details　
Original Abstract of the Article :
The purpose of the study was to assess response rate, clinical outcome, organ/function preservation and toxicity in head and neck cancer patients treated with induction chemotherapy followed by concomitant chemoradiotherapy and, when necessary, limited surgery. The study design was a phase II non-ra...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11788911

データ提供：米国国立医学図書館（NLM）

Head and Neck Cancer Treatment: A Camel's Journey Through the Sands of Oncology

The fight against cancer is a challenging journey, like traversing a vast and unforgiving desert. This phase II study investigates a treatment regimen for advanced head and neck cancer, combining induction chemotherapy with concomitant chemoradiotherapy. The researchers sought to determine the effectiveness of this approach in achieving tumor response, preserving organs and functions, and managing treatment-related toxicity.

A Multifaceted Approach to Cancer Treatment: A Camel's Perspective

The study found that the sequential induction chemotherapy and chemoradiotherapy program demonstrated moderate activity against advanced head and neck cancer. However, it was also associated with significant toxicity, requiring careful monitoring and management. It's like navigating a sandstorm - there are challenges and risks, but with careful planning and preparation, we can find a path forward.

Navigating Cancer Treatment: A Camel's Guide

This study highlights the need for personalized and multidisciplinary approaches to treating head and neck cancer. It reminds us that the journey through cancer treatment is often a complex and challenging one, requiring close collaboration between patients, oncologists, and other healthcare professionals. It's a journey that demands resilience, strength, and hope.

Dr.Camel's Conclusion

This study provides valuable insights into the complex landscape of head and neck cancer treatment. While it highlights the potential of sequential induction chemotherapy and chemoradiotherapy, it also underscores the need for continued research to develop more effective and less toxic treatment strategies. Remember, the fight against cancer is a journey of hope, strength, and collaboration. By working together, we can navigate this challenging terrain and find paths to healing and recovery.

Date :
  1. Date Completed 2002-04-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11788911

DOI: Digital Object Identifier

11788911

Related Literature

Article Analysis
・Effective treatment of head and neck cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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