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Tamoxifen and toremifene cause impairment of learning and memory function in mice.

Author: ChenDuo, ShiBin, WuChun Fu, XuYong Meng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the effects of tamoxifen and toremifene, anti-estrogen drugs used in breast cancer treatment, on memory function in mice. The findings suggest that these drugs may impair different aspects of memory processing, potentially impacting clinical use.
Paper Details　
Original Abstract of the Article :
Tamoxifen (TAM) and toremifene (TOR) are two antiestrogen agents frequently used in the treatment of breast cancer. They are currently being assessed as the prophylactic for patients at high risk of developing tumors. However, the side effects of these drugs on memory function have drawn attention i...See full text at original site
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引用元：
https://doi.org/10.1016/s0091-3057(01)00656-6

データ提供：米国国立医学図書館（NLM）

Tamoxifen and Toremifene: Potential Impacts on Memory Function

The field of [oncology and breast cancer treatment] is constantly striving to improve [therapeutic outcomes] while [minimizing adverse effects]. This study investigates the [potential cognitive side effects] of [tamoxifen (TAM) and toremifene (TOR)], two [antiestrogen agents] commonly used in [breast cancer treatment]. The researchers examined the [impact of TAM and TOR] on [learning and memory function] in [mice] using [behavioral tests].

Navigating the Trade-offs: Balancing Therapeutic Benefits and Cognitive Function

The study found that [TAM and TOR] significantly [impaired memory function] in [mice]. These findings raise [concerns about the potential cognitive side effects] of these drugs in [human patients] and underscore the [importance of considering individual risks and benefits] when [prescribing these medications].

A Call for Awareness: Protecting Cognitive Function in Cancer Treatment

This research emphasizes the [need for continued vigilance] in [monitoring for cognitive changes] in [patients receiving TAM or TOR] treatment. It also highlights the [importance of exploring alternative therapies] or [adjusting treatment strategies] to [minimize cognitive impairment] while maintaining [therapeutic efficacy] in [breast cancer treatment].

Dr. Camel's Conclusion

This study serves as a reminder that even in the pursuit of healing, it's important to consider the potential impact on other aspects of a patient's well-being, like their cognitive function. It's like navigating a shifting sandstorm, where careful attention to every detail is crucial.

Date :
  1. Date Completed 2002-04-05
  2. Date Revised 2019-07-12
Further Info :

Pubmed ID

11812532

DOI: Digital Object Identifier

10.1016/s0091-3057(01)00656-6

Related Literature

Article Analysis
・Side Effects of toremifene
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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