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A double-blind comparison of balsalazide, 6.75 g daily, and sulfasalazine, 3 g daily, in patients with newly diagnosed or relapsed active ulcerative colitis.

Author: GibsonJ A, GreenJ R B, KerrG D, MansfieldJ C, ThorntonP C

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Balsalazide was better tolerated than sulfasalazine in the treatment of active ulcerative colitis of all grades of severity. There was no significant difference in the efficacy of the two medications.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Sulfasalazine is well established in the treatment of active ulcerative colitis. Intolerance to sulfasalazine, however, is a common problem. Balsalazide has been designed to deliver 5-aminosalicylic acid to the colon without the poor tolerability of sulfasalazine. AIM: To compare the sa...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2036.2002.01150.x

データ提供：米国国立医学図書館（NLM）

Balsalazide vs. Sulfasalazine for Ulcerative Colitis

This study explores the treatment options for ulcerative colitis, a condition that causes inflammation in the digestive tract. It's like navigating the treacherous terrain of the digestive system, looking for the best way to soothe inflammation. The researchers compared the safety and effectiveness of two medications, balsalazide and sulfasalazine, in patients with active ulcerative colitis. They found that balsalazide was better tolerated than sulfasalazine, meaning that it caused fewer side effects. This is like finding a smoother path through the desert, one that minimizes discomfort.

Balsalazide: A More Tolerable Option for Ulcerative Colitis

The study showed that balsalazide was better tolerated than sulfasalazine, offering a potential benefit for patients who experience side effects from sulfasalazine. This is like finding a smoother path through the desert, one that minimizes discomfort. The study also found that both medications were equally effective in treating ulcerative colitis.

Finding Relief in the Desert of Digestive Distress

The study offers valuable insights into the management of ulcerative colitis, highlighting the importance of finding treatments that are both effective and well-tolerated. It's a reminder that every patient is different and that their individual needs should be considered when making treatment decisions. This research is a step towards finding better ways to manage this challenging condition.

Dr.Camel's Conclusion

This study is a reminder that even in the challenging desert of digestive disorders, there are often multiple paths to relief. The findings offer valuable information for healthcare providers and patients, highlighting the importance of finding treatments that are both effective and well-tolerated. It's like discovering a hidden oasis of knowledge, one that can help us navigate the complexities of digestive health.

Date :
  1. Date Completed 2002-03-19
  2. Date Revised 2019-09-01
Further Info :

Pubmed ID

11856079

DOI: Digital Object Identifier

10.1046/j.1365-2036.2002.01150.x

Related Literature

Article Analysis
・Effects of balsalazide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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