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Changes in fecal flora and comparative multiple-dose pharmacokinetics of ceftibuten, cefpodoxime proxetil and amoxycillin/clavulanate.
Author: BornerKlaus, BristolDavid, HamacherJürg, KoeppePeter, LodeHartmut, LuepkeJörg, NordCarl Erik, ReidenbergBruce E.
Original Abstract of the Article :
OBJECTIVE: To investigate changes in fecal flora and multiple-dose pharmacokinetics with the oral antibiotics ceftibuten 400 mg daily and cefpodoxime proxetil (CPX) 200 mg every 12 h, compared to amoxycillin/clavulanate 500/125 mg every 8 h during and following 1 week of medication. METHODS: In an o...See full text at original site
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引用元:
https://doi.org/10.1111/j.1469-0691.1999.tb00153.x
データ提供:米国国立医学図書館(NLM)
The Impact of Antibiotics on Fecal Flora: A Comparative Study
This study investigates the effects of three different oral antibiotics (ceftibuten, cefpodoxime proxetil, and amoxycillin/clavulanate) on fecal flora and pharmacokinetics. The authors utilize a randomized triple crossover design to compare the effects of each antibiotic on the composition of gut bacteria. Their findings demonstrate that amoxycillin/clavulanate significantly altered fecal flora compared to the two third-generation cephalosporins (ceftibuten and cefpodoxime proxetil). This research, like a desert expedition, reveals the delicate balance of the human gut microbiome and the potential impact of antibiotics on its composition.
Antibiotics and the Gut: A Balancing Act in the Desert
This study highlights the profound impact that antibiotics can have on the delicate balance of the gut microbiome. The authors demonstrate that certain antibiotics, like amoxycillin/clavulanate, can disrupt the normal composition of gut bacteria, leading to potential side effects. Think of the gut microbiome like a thriving oasis in the desert, where different species of bacteria coexist in harmony. Antibiotics can disrupt this delicate balance, creating a ripple effect that can impact overall health.
Gut Health: A Foundation for Overall Well-being
This research emphasizes the importance of understanding the impact of antibiotics on gut health. This knowledge is crucial for making informed decisions about antibiotic use and minimizing potential side effects. Just as a wise traveler cares for their camel in the desert, we must pay attention to the health of our gut microbiome, ensuring its balance and stability.
Dr. Camel's Conclusion
This study provides valuable insights into the effects of different antibiotics on the gut microbiome. By understanding the potential impact of antibiotics on fecal flora, healthcare professionals can make more informed treatment decisions and minimize the risk of side effects. This research is a reminder that the desert of the human body holds many hidden wonders, including a complex and delicate microbiome that plays a critical role in our health.
Date :
- Date Completed n.d.
- Date Revised 2019-11-20
Further Info :
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