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Azelastine's inhibition of histamine and tryptase release from human umbilical cord blood-derived cultured mast cells as well as rat skin mast cell-induced vascular permeability: comparison with olopatadine.
Author: AthanasiouAchilles, BoucherWilliam, FitzgeraldKim, HuangMan, JeudySheila, KandereKristiana, KempurajDuraisamy, LetourneauRichard, LytinasMichael, SpearKathleen, TheoharidesTheoharis C
Original Abstract of the Article :
Mast cells are involved in early and late-phase reactions by releasing vasoactive molecules, proteases, and cytokines. Azelastine and olopatadine are histamine 1 receptor (H-1R) antagonists with antiallergic effects present in the ophthalmic solutions Optivar and Patanol, respectively. Because it is...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/11894734
データ提供:米国国立医学図書館(NLM)
Azelastine: A Potent Inhibitor of Mast Cell Activation
Mast cells, key players in allergic reactions, release inflammatory mediators like histamine and tryptase. This study investigated the ability of azelastine and olopatadine, two histamine H1 receptor antagonists, to inhibit mast cell activation and mediator release. The researchers found that azelastine, compared to olopatadine, was a more potent inhibitor of mast cell activation, suggesting its potential for treating allergic conditions.
A Tailored Approach to Allergic Reactions
This study, like a camel navigating a maze of sand dunes, explores the specific mechanisms by which different medications can effectively manage allergic reactions. The findings highlight the potential of azelastine as a potent inhibitor of mast cell activation, offering a more targeted approach to treating allergic conditions.
AzeLasting Relief for Allergic Symptoms
For individuals suffering from allergies, this research offers a ray of hope. Azelastine's potent ability to inhibit mast cell activation suggests its potential for providing effective relief from allergic symptoms. It's important to consult with a healthcare professional to determine the most appropriate treatment for your specific allergies.
Dr.Camel's Conclusion
This study sheds light on the intricate mechanisms of allergic reactions and the potential of targeted therapies like azelastine to effectively manage these conditions. The research highlights the importance of individualized treatment approaches to address the unique needs of individuals with allergies.
Date :
- Date Completed 2002-08-21
- Date Revised 2020-09-29
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