Anti-endotoxic shock effects of cyproheptadine in rats.

Author: HuXiuzhou, LunNing, WangBaosheng, WangLizan, ZhangQingzhu, ZhuFanhe

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To investigate the antagonistic effect and mechanism of the effect of cyproheptadine (Cyp) on endotoxic shock in rats. METHODS: Endotoxic shock was produced in rats by i.v. injection of lipopolysaccharides (LPS) (5 mg/kg). Tumor necrosis factor (TNF(alpha)) mRNA expression was assessed b...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/11940385

データ提供:米国国立医学図書館(NLM)

Fighting Shock: The Protective Effects of Cyproheptadine

Endotoxic shock, a potentially life-threatening condition triggered by bacterial toxins, is a serious medical challenge. This research investigates the protective effects of cyproheptadine, a medication commonly used for allergies, against endotoxic shock. The study focused on the mechanisms by which cyproheptadine exerts its protective effects, analyzing its impact on key factors such as tumor necrosis factor (TNF-alpha) production, oxidative stress, and intracellular calcium levels.

A Multifaceted Approach: Combating Endotoxic Shock

The study's findings suggest that cyproheptadine has a multi-pronged approach to combating endotoxic shock. The medication effectively reduced TNF-alpha production, a key mediator of inflammation and tissue damage in endotoxic shock. Cyproheptadine also exhibited antioxidant properties, reducing oxidative stress and protecting cells from damage. Additionally, the medication was found to inhibit the elevation of intracellular calcium levels, a critical factor in the development of endotoxic shock.

Understanding the Body's Response: A Key to Effective Treatment

The study's findings shed light on the complex mechanisms involved in endotoxic shock and highlight the potential of cyproheptadine as a therapeutic agent. The research underscores the importance of understanding the body's intricate responses to infection and inflammation in order to develop effective treatments.

Dr.Camel's Conclusion

Endotoxic shock, like a sudden desert sandstorm, can be dangerous and unpredictable. This study provides a beacon of hope, exploring the protective effects of cyproheptadine against this potentially life-threatening condition. The research emphasizes the importance of understanding the intricate mechanisms of inflammation and seeking multifaceted approaches to combat this serious medical challenge.

Date :
  1. Date Completed 2002-05-01
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11940385

DOI: Digital Object Identifier

11940385

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PICO Info
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Languages

English

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