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Next generation antihistamines: therapeutic rationale, accomplishments and advances.

Author: CasaleThomas B, OppenheimerJohn J

Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the evolution of antihistamines, highlighting the development of newer generations with improved safety and efficacy profiles. First-generation antihistamines have significant sedative effects, while second-generation agents were associated with rare but serious cardiac side effects. Third-generation antihistamines, often metabolites of earlier drugs, have demonstrated no cardiac effects and offer improved pharmacokinetic and pharmacodynamic properties.
Paper Details　
Original Abstract of the Article :
Antihistamines, among the most commonly prescribed drugs in the world, have evolved considerably since the first generation was introduced >50 years ago. The first generation antihistamines (e.g., chlorpheniramine, diphenhydramine, promethazine and hydroxyzine) are still widely available and in use ...See full text at original site
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引用元：
https://doi.org/10.1517/13543784.11.6.807

データ提供：米国国立医学図書館（NLM）

The Evolution of Antihistamines: A Journey Through Generations

Antihistamines, medications used to alleviate allergic reactions, have undergone significant advancements since their initial introduction decades ago. This review traces the evolution of antihistamines, examining the therapeutic rationale, accomplishments, and advancements of different generations of these drugs. The researchers discuss the development of first, second, and third-generation antihistamines, highlighting their respective advantages and disadvantages.

A Continual Search for Improved Antihistamine Therapies

The review highlights the ongoing quest for more effective and safer antihistamines. Researchers have successfully developed newer generations of antihistamines with improved pharmacokinetic and pharmacological properties, reducing sedative effects and minimizing the risk of cardiovascular complications.

A Better Quality of Life for Allergy Sufferers

This review underscores the significant progress made in the development of antihistamines, offering hope for improved quality of life for individuals with chronic allergies. The emergence of newer generations of antihistamines with enhanced efficacy and safety profiles provides valuable tools for managing allergic reactions.

Dr.Camel's Conclusion

Just as a desert landscape can be transformed by a refreshing oasis, the development of antihistamines has brought relief to those suffering from allergies. This review highlights the continuous journey of research and innovation in the quest for improved antihistamine therapies, offering hope for a more comfortable life for allergy sufferers.

Date :
  1. Date Completed 2002-11-20
  2. Date Revised 2019-09-16
Further Info :

Pubmed ID

12036424

DOI: Digital Object Identifier

10.1517/13543784.11.6.807

SNS
PICO Info
in preparation
Languages

English

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