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Nitazoxanide pharmacokinetics and tolerability in man using single ascending oral doses.

Author: AllemonA M, De BruynS, GenglerC, StockisA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This phase IA study assessed the tolerability and pharmacokinetic linearity of tizoxanide (T) and its glucuronide (TG), metabolites of nitazoxanide (N), in healthy volunteers. The study aimed to determine the pharmacokinetic profile of T and TG after single-dose administration of N with and without food.
Paper Details　
Original Abstract of the Article :
Nitazoxanide (N) is a new broad-spectrum intestinal antiparasitic agent. Deacetyl-N or tizoxanide (T) and its glucuronide (TG) are the major circulating species metabolites after oral administration of N. Bioavailability is substantially increased by food. The objectives of this phase IA study were ...See full text at original site
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引用元：
https://doi.org/10.5414/cpp40213

データ提供：米国国立医学図書館（NLM）

The Nitty-Gritty of Nitazoxanide

Pharmacology is a fascinating field, much like navigating a vast desert - full of surprises and challenges. This research dives into the world of nitazoxanide, a promising antiparasitic agent for intestinal infections. The study employed a single ascending dose approach in healthy volunteers, exploring the tolerability and pharmacokinetic linearity of nitazoxanide's major circulating metabolites, tizoxanide and its glucuronide. The researchers discovered that the bioavailability of nitazoxanide is significantly enhanced by food, a finding that has potential implications for treatment regimens.

Food for Thought: Impact on Nitazoxanide's Bioavailability

This study revealed a crucial insight: Food significantly boosts the absorption of nitazoxanide in the body. Just like a camel needs water to thrive in the desert, nitazoxanide seems to need the presence of food to reach its full potential. This discovery could lead to improved treatment strategies, ensuring that nitazoxanide is more effectively absorbed and can tackle intestinal parasites more efficiently.

A Bite to Eat: How Food Affects Nitazoxanide

The researchers found that eating food along with nitazoxanide significantly increased its bioavailability, leading to higher concentrations of the drug in the bloodstream. This is like adding fuel to the fire - the presence of food makes nitazoxanide more powerful in its fight against parasites. This finding underscores the importance of considering dietary factors when administering medications and emphasizes the need for further research to optimize nitazoxanide's effectiveness.

Dr. Camel's Conclusion

This study sheds light on the fascinating interplay between food and medication. Like a desert oasis offering sustenance to weary travelers, food seems to play a crucial role in enhancing nitazoxanide's effectiveness. This research opens new avenues for optimizing treatment strategies and understanding the intricate relationship between what we eat and how our bodies respond to medications.

Date :
  1. Date Completed 2002-11-25
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

12051573

DOI: Digital Object Identifier

10.5414/cpp40213

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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