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Lipid formulation as a drug carrier for drug delivery.

Author: TomiiYoshifumi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study discusses the use of lipid nanospheres (LNS) as a novel drug delivery system for amphotericin B (AmB), an antifungal agent. LNS can improve AmB's efficacy and reduce its toxicity. The study highlights LNS's ability to deliver high drug concentrations while minimizing uptake by the reticuloendothelial system, a major challenge with other lipid formulations.
Paper Details　
Original Abstract of the Article :
In recent years, a Drug Delivery System (DDS), a preparative approach attracts the attention in the development of new drugs. DDS focuses on the regulation of the in vivo dynamics, such as absorption, distribution, metabolism, and elimination, thereby improving the effectiveness and the safety of th...See full text at original site
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引用元：
https://doi.org/10.2174/1381612023395871

データ提供：米国国立医学図書館（NLM）

Lipid Formulation as a Drug Carrier for Drug Delivery

The field of drug delivery is a vast desert, where researchers are constantly searching for innovative ways to improve the effectiveness and safety of medications. This research, like a skilled caravan leader, explores the potential of lipid formulations as drug carriers, focusing on amphotericin B (AmB), a powerful antifungal drug. AmB, though effective in treating fungal infections, is known for its harsh side effects. The study examines the use of lipid formulations like liposomal AmB (L-AmB), AmB lipid complex (ABLC), and AmB colloidal dispersion (ABCD) to reduce these adverse effects. The researchers also introduce a novel drug carrier, Lipid Nano-Sphere (LNS), which is designed to enhance drug delivery and minimize side effects.

Lipid Formulations: A New Oasis in Drug Delivery

The researchers found that these lipid formulations, like refreshing oases in the desert, offer significant advantages over traditional AmB delivery methods. They report that these formulations demonstrate improved safety and efficacy compared to conventional AmB, reducing the risk of side effects while maintaining therapeutic effectiveness. The study also highlights the potential of LNS, a new type of lipid carrier, which shows promising results in both in vitro and in vivo studies, further expanding the options for safe and effective drug delivery.

Navigating the Challenges of Drug Delivery

This study underscores the importance of innovative drug delivery strategies to improve treatment outcomes and minimize side effects. The development of lipid formulations, particularly the promising LNS, offers a glimmer of hope in the desert of drug delivery challenges, paving the way for more effective and patient-friendly therapies.

Dr. Camel's Conclusion

This study explores the exciting landscape of lipid formulations as drug carriers, offering a promising solution to the challenges of drug delivery. The development of these innovative delivery systems is like finding a new oasis in the desert, providing a path toward safer and more effective treatment options for patients.

Date :
  1. Date Completed 2004-06-22
  2. Date Revised 2019-07-28
Further Info :

Pubmed ID

12069383

DOI: Digital Object Identifier

10.2174/1381612023395871

SNS
PICO Info
in preparation
Languages

English

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