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A pharmacokinetic interaction study between butorphanol and sumatriptan nasal sprays in healthy subjects: importance of the timing of butorphanol administration.

Author: BoultonD W, NicholaP S, ShyuW-C, VachharajaniN N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

This study found that administering butorphanol nasal spray less than 30 minutes after sumatriptan nasal spray can reduce the effectiveness of butorphanol due to vasoconstriction caused by sumatriptan.
Paper Details　
Original Abstract of the Article :
Sumatriptan and butorphanol nasal sprays are commonly used agents for the management of migraine headaches. Under certain circumstances, these two agents may be administered closely in time. However, the possibility of a pharmacokinetic interaction and the safety of this regime have not been examine...See full text at original site
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引用元：
https://doi.org/10.1046/j.1468-2982.2002.00359.x

データ提供：米国国立医学図書館（NLM）

Decoding the Complexities of Migraine Treatment

This study delves into the world of migraine headaches and the intricate interaction of medications used to treat them. Imagine a caravan traveling through the desert, facing the scorching heat of a migraine. This study examines two common medications used to treat migraines: sumatriptan and butorphanol, both administered nasally.

Timing is Key

The study reveals that the timing of butorphanol administration in relation to sumatriptan can significantly impact its effectiveness. Think of it like this: A caravan crossing a desert must carefully navigate the shifting sands, and the timing of their journey is crucial. If butorphanol is administered too soon after sumatriptan, its absorption is reduced due to vasoconstriction caused by sumatriptan. This study found that administering butorphanol at least 30 minutes after sumatriptan minimized this interaction.

Navigating the Migraine Desert

The study provides crucial insights for physicians and patients alike, emphasizing the importance of timing when administering these medications. This knowledge can help optimize treatment strategies and ensure the most effective relief from migraine headaches.

Dr.Camel's Conclusion

Just as a caravan needs a strategic approach to cross a challenging desert, treating migraines requires careful consideration of medication timing. This study provides invaluable guidance for navigating the complexities of migraine management, ensuring that each step is taken with the utmost care and precision.

Date :
  1. Date Completed 2002-09-10
  2. Date Revised 2017-02-14
Further Info :

Pubmed ID

12100090

DOI: Digital Object Identifier

10.1046/j.1468-2982.2002.00359.x

Related Literature

Article Analysis
・Effects of sumatriptan nasal
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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