Paper Details

  1. Home
  2. Paper Details

Systemic bioavailability and cardiopulmonary effects of 0.5% timolol eyedrops.

Author: KailaTimo, KorteJuha-Matti, SaariK Matti

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ophthalmic timolol resembles intravenous timolol in terms of systemic bioavailability, plasma kinetics, and cardiopulmonary effects.
Paper Details　
Original Abstract of the Article :
BACKGROUND: To investigate the pharmacological basis of systemic side effects of ophthalmic timolol, we estimated the systemic bioavailability of 0.5% timolol eyedrops and compared cardiopulmonary effects of intravenous and ophthalmic timolol. METHODS: In a randomized crossover study we administere...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s00417-002-0462-2

データ提供：米国国立医学図書館（NLM）

Timolol Eyedrops: Systemic Effects and Cardiopulmonary Implications

Ophthalmology, the branch of medicine focused on the eye, constantly seeks to improve treatment options for various eye conditions. This research delves into the systemic effects of timolol, a beta-blocker commonly used in eyedrops, investigating its bioavailability and cardiopulmonary impact. The study meticulously measured the systemic bioavailability of 0.5% timolol eyedrops, comparing its effects on heart rate, blood pressure, and pulmonary function to those of intravenous timolol administration.

Timolol's Systemic Bioavailability and Cardiopulmonary Effects

The study revealed that timolol eyedrops exhibit significant systemic bioavailability, reaching comparable plasma concentrations to intravenous timolol. The research also found that both intravenous and ocular timolol administration produced similar effects on heart rate, blood pressure, and pulmonary function. This finding underscores the importance of considering the potential systemic effects of timolol eyedrops, especially in patients with underlying cardiovascular or respiratory conditions.

Navigating Timolol Eyedrops: A Balanced Approach

This research highlights the need for a balanced approach when using timolol eyedrops, considering the potential for systemic effects, particularly in patients with pre-existing cardiovascular or respiratory conditions. While timolol eyedrops can effectively lower intraocular pressure, healthcare professionals must carefully weigh the potential benefits against the potential risks. This research underscores the importance of individualized patient assessment and careful monitoring to ensure the safe and effective use of timolol eyedrops.

Dr.Camel's Conclusion

This study, like a desert explorer meticulously mapping a vast landscape, reveals the systemic effects of timolol eyedrops. It emphasizes the importance of considering the potential for systemic bioavailability and its implications for patients with underlying health conditions. This research reminds us that even seemingly localized treatments can have broader effects on the body, requiring a comprehensive understanding of their potential impact.

Date :
  1. Date Completed 2002-10-03
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

12107508

DOI: Digital Object Identifier

10.1007/s00417-002-0462-2

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.