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Nadolol is superior to isosorbide mononitrate for the prevention of the first variceal bleeding in cirrhotic patients with ascites.

Author: BissoliFranco, BorroniGianmario, CazzanigaMassimo, LorenzanoElettra, MaggiAlessandra, PanzeriAnna, SalernoFrancesco, VisentinStefania, de FranchisRoberto

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the efficacy and applicability of nadolol and isosorbide-mononitrate (IsMn) in preventing first variceal bleeding (FVB) in cirrhotic patients with ascites. The study found that IsMn may be a suitable alternative to beta-blockers for preventing FVB in patients with ascites who cannot tolerate beta-blockers.
Paper Details　
Original Abstract of the Article :
beta-blockers effectively prevent first variceal bleeding (FVB) in cirrhotic patients. In patients with ascites, however, their use might be precluded by a high rate of contraindications and side effects. We compared the efficacy and applicability of nadolol and isosorbide-mononitrate (IsMn) in prev...See full text at original site
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引用元：
https://doi.org/10.1016/s0168-8278(02)00174-5

データ提供：米国国立医学図書館（NLM）

Preventing Variceal Bleeding: Nadolol vs. Isosorbide Mononitrate

The delicate balance of blood flow in the liver is a complex dance, and when variceal bleeding occurs, it's a crucial situation that requires careful attention. This study delves into the realm of preventive strategies for variceal bleeding in patients with cirrhosis and ascites, exploring the effectiveness of two medications: nadolol and isosorbide mononitrate.

Nadolol Shows Promise for Variceal Bleeding Prevention

The study suggests that nadolol might be superior to isosorbide mononitrate in preventing variceal bleeding in patients with ascites. This finding is akin to finding a reliable source of water in the desert, offering a lifeline to those at risk of bleeding episodes.

Understanding Variceal Bleeding and Ascites

Variceal bleeding occurs when enlarged blood vessels in the esophagus or stomach rupture, often a consequence of liver disease. Ascites, the accumulation of fluid in the abdomen, further complicates the situation. It's like navigating a desert with a leaky canteen, making it essential to find the right solutions to manage fluid balance and prevent complications.

Dr.Camel's Conclusion

This study highlights the importance of personalized treatment approaches for patients with cirrhosis and ascites. Finding the right medication to prevent variceal bleeding is essential, and this research suggests that nadolol might be a promising option. As we continue to explore the vast landscape of liver health, we must prioritize patient safety and find the most effective strategies to manage these complex conditions.

Date :
  1. Date Completed 2003-04-07
  2. Date Revised 2019-08-17
Further Info :

Pubmed ID

12175626

DOI: Digital Object Identifier

10.1016/s0168-8278(02)00174-5

Related Literature

Article Analysis
・Side Effects of nadolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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