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Phase III study of ibuprofen versus placebo for radiation-induced genitourinary side effects.

Author: BeardClair, ColemanC Norman, KaplanIrving, KellyLaura, LambCarolyn, ManolaJudith, PropertKathleen, Riese DalyNancy

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Ibuprofen, a nonsteroidal anti-inflammatory agent, was not effective in reducing urinary symptoms during radiotherapy for prostate cancer.
Paper Details　
Original Abstract of the Article :
On the basis of our anecdotal clinical observations that nonsteroidal anti-inflammatory agents relieved dysuria during radiotherapy for patients with prostate cancer, we conducted a Phase III randomized trial of ibuprofen vs. placebo for patients who had an increase in acute urinary symptoms. Our in...See full text at original site
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引用元：
https://doi.org/10.1016/s0360-3016(02)02907-3

データ提供：米国国立医学図書館（NLM）

Ibuprofen: A Potential Relief for Radiation-Induced Genitourinary Side Effects

Radiation therapy is a common treatment for prostate cancer, but it can cause uncomfortable side effects, including urinary symptoms. This Phase III trial investigates the potential of ibuprofen to alleviate these side effects.

Ibuprofen: A Potential Oasis for Radiation-Induced Symptoms

This study found that ibuprofen did not significantly reduce urinary symptoms in patients undergoing radiotherapy for prostate cancer. While ibuprofen is a commonly used anti-inflammatory drug, the results of this trial suggest that it may not be effective for relieving radiation-induced genitourinary side effects.

Navigating the Desert of Radiation Therapy: A Need for Alternative Approaches

This study highlights the need for alternative strategies to manage radiation-induced genitourinary side effects. It's like searching for a new oasis in the desert of radiation therapy. Further research is needed to identify more effective treatments for these challenging side effects.

Dr.Camel's Conclusion

Ibuprofen may not be the solution for radiation-induced genitourinary side effects, but the search for effective treatments continues. It's like exploring a vast desert – while we may encounter some dead ends, the journey continues until we find a true oasis of relief.

Date :
  1. Date Completed 2002-09-26
  2. Date Revised 2019-07-08
Further Info :

Pubmed ID

12182991

DOI: Digital Object Identifier

10.1016/s0360-3016(02)02907-3

Related Literature

Article Analysis
・Side Effects of ibuprofen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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