Effects of cigarette smoking and nicotine nasal spray on psychiatric symptoms and cognition in schizophrenia.

Author: InfanteMauricio, KhandatAmaresh, KloosAngelica, SinghAbhay, SmithRobert C

Paper Details 
Original Abstract of the Article :
Schizophrenic patients have among the highest rates of smoking of any group of patients. Previous studies have identified psychophysiological and potential nicotinic receptor abnormalities which may be associated with this phenomenon. The effects of acute smoking or acute administration of nicotine ...See full text at original site
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引用元:
https://doi.org/10.1016/S0893-133X(02)00324-X

データ提供:米国国立医学図書館(NLM)

Schizophrenia and Smoking: Unraveling the Connection

Schizophrenia is a complex mental illness that often presents with unique challenges. This study explores the relationship between schizophrenia, smoking, and nicotine, delving into the potential impact on psychiatric symptoms and cognitive function. Schizophrenic patients, as this research reveals, have significantly higher smoking rates compared to other patient populations. This study investigates the effects of acute smoking and nicotine nasal spray on various aspects of schizophrenia, including negative symptoms, cognitive function, and overall mental state.

Nicotine's Role: A Complex Puzzle

The study found that smoking high-nicotine cigarettes was associated with a decrease in negative symptoms compared to denicotinized cigarettes. However, the impact of smoking on positive symptoms, anxiety, and depression was not statistically significant. Interestingly, nicotine nasal spray did not show a significant reduction in negative symptoms, but it did improve performance on a spatial organization task and showed a trend towards improvement in some measures of verbal memory and reaction time. These findings suggest that nicotine might play a role in alleviating certain symptoms of schizophrenia, but further research is needed to fully understand the mechanisms involved.

Navigating the Complexities of Treatment: A Holistic Approach

The study's results emphasize the need for a nuanced approach to treating schizophrenia. While nicotine may offer potential benefits for specific symptoms, it's crucial to consider the broader health implications of smoking. This research underscores the importance of personalized treatment strategies tailored to individual patient needs and the complexities of the disorder.

Dr.Camel's Conclusion

The relationship between schizophrenia, smoking, and nicotine is a complex desert landscape, full of hidden oases and treacherous dunes. As researchers, we must continue to navigate this landscape, seeking to understand the intricate interplay between these factors. The goal is to find a path that leads to better treatment options and improved quality of life for individuals with schizophrenia.

Date :
  1. Date Completed 2002-11-15
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

12225705

DOI: Digital Object Identifier

10.1016/S0893-133X(02)00324-X

Related Literature

SNS
PICO Info
in preparation
Languages

English

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