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The efficacy of combined zidovudine and lamivudine compared with that of combined zidovudine, lamivudine and nelfinavir in asymptomatic and early symptomatic HIV-infected children.

Author: LikanonsakulSirirat, MoolasartPikul

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the efficacy of two treatment regimens, double-drug therapy (ZDV+3TC) and triple-drug therapy (ZDV+3TC+NFV), in 25 HIV-infected children over 6 months. Although the triple-drug therapy showed higher median weight increase (24% vs. 2%), CD4-cell count increase (94.5% vs. 9.4%), and viral load reduction (1.2 log10; 20.8% vs. 0.72 log10; 13.8%), these differences were not statistically significant. Both regimens were well tolerated, with no side effects or deaths.
Paper Details　
Original Abstract of the Article :
In this 6-month prospective study, we compared the efficacy of two treatment regimens: double-drug therapy with zidovudine (ZDV) and lamivudine (3TC) and triple-drug therapy with ZDV plus 3TC plus nelfinavir (NFV), in the treatment of asymptomatic and early symptomatic HIV-infected children. Twenty-...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12236426

データ提供：米国国立医学図書館（NLM）

HIV Treatment in Children: Comparing Double and Triple-Drug Therapies

This study examines the efficacy of different treatment regimens for HIV-infected children. The authors compare the outcomes of double-drug therapy (zidovudine and lamivudine) with triple-drug therapy (zidovudine, lamivudine, and nelfinavir) in asymptomatic and early symptomatic children. They assess the impact of each regimen on key clinical parameters, including weight, CD4 cell count, viral load, and side effects. Their findings provide valuable insights into the effectiveness and safety of these treatment options for HIV-infected children.

Double vs. Triple-Drug Therapies: No Significant Difference in Efficacy

This study demonstrates that both double-drug and triple-drug therapies are well-tolerated and effective in managing HIV infection in children. While triple-drug therapy showed a trend towards better outcomes in terms of weight gain, CD4 cell count increase, and viral load reduction, the differences were not statistically significant. These findings suggest that both regimens are viable options for treating HIV in children, with potential benefits and risks to be considered on a case-by-case basis.

Tailoring Treatment to Individual Needs

This research emphasizes the importance of tailoring HIV treatment to the specific needs of each child. While both double-drug and triple-drug therapies demonstrated effectiveness, the choice of regimen should be guided by individual factors such as disease stage, tolerance, and potential side effects. This highlights the need for individualized care plans and close monitoring to optimize HIV treatment in children.

Dr.Camel's Conclusion

Like the shifting sands of the desert, HIV treatment strategies continue to evolve. This study sheds light on the effectiveness of different treatment regimens for HIV-infected children, emphasizing the importance of personalized care and ongoing research to optimize treatment outcomes.

Date :
  1. Date Completed 2003-01-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

12236426

DOI: Digital Object Identifier

12236426

Related Literature

Article Analysis
・Side Effects of nelfinavir・Side Effects of zdv
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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