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A randomized, double-blind, multicenter, parallel group study to compare relative efficacies of the topical gels 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4% in the treatment of moderate acne vulgaris of the face.

Author: AminSmita, ChoiKen, GoldsteinEric, GuptaAditya K, KunynetzRod A W, LyndeCharles W

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Combination treatments for acne, like Benzamycin (erythromycin and benzoyl peroxide) and Stievamycin (tretinoin and erythromycin), are effective because they target different aspects of acne. Erythromycin in both treatments reduces bacteria that contribute to inflammation. Benzoyl peroxide in Benzamycin has both antibacterial and anti-comedogenic (pore-clearing) properties. Tretinoin in Stievamycin helps normalise skin cell turnover and loosen the blockage that forms comedones. Combining antibiotics can reduce the risk of resistance, and the tretinoin/erythromycin combination provides both antibacterial and cell-regulating effects.
Paper Details　
Original Abstract of the Article :
Combination treatments for acne vulgaris, such as Benzamycin (3% erythromycin/5% benzoyl peroxide) and Stievamycin (0.025% tretinoin/erythromycin 4%), reduce bacterial growth, which contributes to the inflammatory lesions typical of adolescent acne, and also decrease the epidermal cell compaction wh...See full text at original site
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引用元：
https://doi.org/10.1007/s10227-002-2101-2

データ提供：米国国立医学図書館（NLM）

The Shifting Sands of Acne Treatment: A Tale of Two Topical Gels

The world of dermatology offers a wide range of treatments for acne vulgaris, a common skin condition that affects millions. This study compares the efficacy of two topical gels: Benzamycin (3% erythromycin/5% benzoyl peroxide) and Stievamycin (0.025% tretinoin/erythromycin 4%). The researchers conducted a randomized, double-blind, multicenter, parallel group study to assess the relative effectiveness of these two gels in treating moderate acne vulgaris. The study revealed that both treatments were effective in reducing acne lesions, highlighting the multifaceted approach required to manage this complex skin condition.

The Shifting Sands of Acne Treatment: A Tale of Two Topical Gels

The study's findings suggest that both Benzamycin and Stievamycin are effective options for treating moderate acne vulgaris. The authors highlight the importance of individualized treatment approaches based on patient characteristics and preferences. The study also underscores the need for further research to explore the long-term efficacy and safety of these topical gels.

The Shifting Sands of Acne Treatment: A Tale of Two Topical Gels

If you're struggling with acne, it's important to consult with a dermatologist to develop a personalized treatment plan. There are a variety of options available, and finding the right approach can help you achieve clearer skin.

Dr. Camel's Conclusion

Acne treatment is a journey through the shifting sands of different therapies. This study reveals that both Benzamycin and Stievamycin offer promising paths to clearer skin, but the best approach will vary depending on individual needs. Remember, patience and persistence are key in the quest for a blemish-free complexion.

Date :
  1. Date Completed 2003-07-01
  2. Date Revised 2019-11-06
Further Info :

Pubmed ID

12362264

DOI: Digital Object Identifier

10.1007/s10227-002-2101-2

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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