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The effects of ultrafiltration on e-aminocaproic acid: an in vitro analysis.

Author: KmiecikScott A, KohtzRyan J, LiuJun-Li, MillsNancy J, NicholsJeffrey D, PettersonCraig M, StammersAlfred H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Continuous ultrafiltration was shown to maintain the antifibrinolytic properties of e-aminocaproic acid (EACA) while reducing total circulating volume by 25%. This study demonstrated the potential for combining ultrafiltration with EACA in blood conservation strategies during cardiac surgery.
Paper Details　
Original Abstract of the Article :
Blood conservation strategies have become a standard of practice in cardiac surgery, with the use of antifibrinolytic agents and ultrafiltration two popular techniques. The purpose of this study was to evaluate the effects of continuous ultrafiltration on e-aminocaproic acid (EACA) utilizing functio...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12395966

データ提供：米国国立医学図書館（NLM）

Ultrafiltration's Impact on e-aminocaproic Acid: A Vital Consideration for Blood Conservation

Blood conservation strategies are essential in cardiac surgery, often involving the use of antifibrinolytic agents, such as e-aminocaproic acid (EACA), and ultrafiltration. This research investigates the impact of continuous ultrafiltration on EACA's effectiveness using functional coagulation analysis. The study found that while ultrafiltration did lead to a reduction in circulating EACA levels, the antifibrinolytic properties of EACA were maintained. This suggests that ultrafiltration can be used safely in conjunction with EACA for blood conservation strategies.

A Balancing Act in Blood Conservation

This research helps us better understand the interplay between ultrafiltration and EACA, highlighting the importance of careful monitoring to ensure optimal blood conservation strategies. The study underscores the need for a delicate balance between removing excess fluid and maintaining sufficient levels of EACA to prevent excessive bleeding.

Navigating the Sands of Blood Conservation

Imagine the vast desert, where water is a precious resource. In the same way, blood conservation is crucial in cardiac surgery. This research provides valuable insights into the impact of ultrafiltration on EACA, helping us navigate the delicate balance of fluid management and blood conservation.

Dr. Camel's Conclusion

This research reveals that ultrafiltration does not compromise the effectiveness of e-aminocaproic acid, offering important information for optimizing blood conservation strategies in cardiac surgery.

Date :
  1. Date Completed 2002-11-20
  2. Date Revised 2015-10-30
Further Info :

Pubmed ID

12395966

DOI: Digital Object Identifier

12395966

Related Literature

Article Analysis
・Effects of aminocaproic acid
SNS
PICO Info
in preparation
Languages

English

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