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Pharmacokinetics, dose proportionality, and tolerability of single and repeat doses of a nasal spray formulation of zolmitriptan in healthy volunteers.

Author: DaneA L, DixonRuth, KempJ V, NairnKevin, YatesRoger

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the pharmacokinetics, dose proportionality, and tolerability of zolmitriptan nasal spray in healthy volunteers across a range of doses. Zolmitriptan was well-tolerated, and dose proportionality was demonstrated for both zolmitriptan and its active metabolite.
Paper Details　
Original Abstract of the Article :
The objective of this study was to investigate the pharmacokinetics, dose proportionality, and tolerability of a range of single and multiple doses of a nasal spray formulation of zolmitriptan in a randomized, double-blind, placebo-controlled, balanced, incomplete crossover study. Thirty healthy mal...See full text at original site
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引用元：
https://doi.org/10.1177/009127002762491334

データ提供：米国国立医学図書館（NLM）

Navigating the Terrain of Migraine Treatment: A Nasal Spray Formulation of Zolmitriptan

Migraine headaches can be a debilitating condition, often leaving individuals feeling overwhelmed and unable to function. This study explores the potential of a nasal spray formulation of zolmitriptan, a medication commonly used to treat migraines, as a new and convenient approach to delivering this medication. Researchers aimed to evaluate the pharmacokinetics, dose proportionality, and tolerability of this nasal spray formulation in healthy volunteers, exploring its potential as a safe and effective treatment option. Their findings revealed that the nasal spray formulation of zolmitriptan was well-tolerated, with minimal side effects and a predictable dose-response relationship. This suggests that this formulation could provide an alternative to traditional oral medications, potentially improving patient compliance and treatment outcomes.

Exploring New Horizons: Nasal Spray Formulation of Zolmitriptan Offers Promise

This study offers a promising new horizon in migraine treatment, showcasing the potential of a nasal spray formulation of zolmitriptan as a safe and effective alternative to traditional oral medications. Its convenient delivery route and favorable pharmacokinetic profile suggest its potential to improve patient compliance and enhance treatment outcomes.

A New Path to Pain Relief: Navigating the Desert of Migraine Treatment

This research highlights the continuous search for innovative and patient-friendly approaches to migraine treatment. The development of a nasal spray formulation of zolmitriptan opens up new pathways for pain relief, potentially improving the lives of those suffering from this debilitating condition.

Dr. Camel's Conclusion

This study is a reminder that the journey to manage migraine headaches is a long and challenging one, much like traversing a vast and unforgiving desert. The development of a nasal spray formulation of zolmitriptan offers a new and convenient way to navigate this terrain, potentially leading to improved outcomes for patients.

Date :
  1. Date Completed 2003-03-14
  2. Date Revised 2019-08-26
Further Info :

Pubmed ID

12412823

DOI: Digital Object Identifier

10.1177/009127002762491334

Related Literature

Article Analysis
・Effects of zolmitriptan nasal spray
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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