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Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines.

Author: HattoriTakanori, KashimaKei, MitsufujiShoji, NodaMasao, SugiharaHiroyuki, TakamaTakafumi, TatsumiYoichi, TomizawaMuneta

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the effect of a COX-2 inhibitor on the proliferation and expression of E-cadherin-complexes in gastrointestinal cancer cell lines. COX-2 inhibitors may affect cell proliferation by modulating the cadherin-catenin complex, which plays a role in cell adhesion and proliferation.
Paper Details　
Original Abstract of the Article :
Recent studies have shown that cyclooxygenase-2 (COX-2) inhibitors may participate in the proliferation of cancer cells. Because the cadherin-catenin complex is not only a key component of the adherens junction but also has been suggested to regulate cell proliferation, modulation of these molecules...See full text at original site
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引用元：
https://doi.org/10.1007/s005350200151

データ提供：米国国立医学図書館（NLM）

Effects of Etodolac, a Selective Cyclooxygenase-2 Inhibitor, on the Expression of E-Cadherin-Catenin Complexes in Gastrointestinal Cell Lines

The intricate world of gastrointestinal cells is like a bustling desert city, where the E-cadherin-catenin complex acts as a vital regulatory system for cell growth and adhesion. This study explores the effects of etodolac, a selective cyclooxygenase-2 (COX-2) inhibitor, on this crucial complex, examining its potential impact on the city's development.

Etodolac: A Potential Influence on Cell Growth

The study found that etodolac can modulate the expression of the E-cadherin-catenin complex in gastrointestinal cell lines. It's like introducing a new desert plant that can influence the city's growth and development, possibly influencing the balance of cell growth and adhesion. The study's findings suggest a potential link between COX-2 inhibition and cell proliferation, highlighting a new area of research in gastrointestinal cell biology.

Understanding the Complexities of Cell Regulation

This research underscores the complex interplay of different molecules and pathways within cells. Understanding the intricate workings of the desert city of gastrointestinal cells is crucial for developing new therapies to combat diseases affecting this vital organ system.

Dr.Camel's Conclusion

This study offers a glimpse into the fascinating and complex world of cellular regulation. Just like a desert oasis, the gastrointestinal system is a delicate balance of intricate pathways and interactions. The study's findings highlight the importance of further research to understand the potential influence of COX-2 inhibitors on cell growth and development, contributing to a deeper understanding of this vital organ system.

Date :
  1. Date Completed 2003-03-12
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

12483244

DOI: Digital Object Identifier

10.1007/s005350200151

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・Effects of etodolac
SNS
PICO Info
in preparation
Languages

English

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