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Systematic review: serotonergic modulators in the treatment of irritable bowel syndrome--influence on psychiatric and gastrointestinal symptoms.

Author: BrummerR-J M, HonigA, KilkensT O C, RozendaalN, Van NieuwenhovenM A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Medications that affect serotonin, a brain chemical, are used to treat irritable bowel syndrome (IBS). Many people with IBS also experience mood problems. Serotonin may play a role in both digestive function and mood regulation in people with IBS.
Paper Details　
Original Abstract of the Article :
Both central and peripheral serotonergic modulators are used in the treatment of irritable bowel syndrome. The majority of patients with irritable bowel syndrome presenting to a gastroenterologist demonstrate affective dysregulation. Serotonin may play a regulatory role in both gastrointestinal moti...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2036.2003.01388.x

データ提供：米国国立医学図書館（NLM）

Irritable Bowel Syndrome: Unraveling the Role of Serotonin

This systematic review, like a meticulous exploration of a complex desert ecosystem, investigates the role of serotonergic modulators in the treatment of irritable bowel syndrome (IBS), a condition that affects the digestive system, like a delicate balance in the desert's ecosystem. The researchers, like skilled desert ecologists, delve into the intricate interplay between serotonin and IBS symptoms, seeking to understand the mechanisms underlying this common disorder.

A Symphony of Signals: Serotonin's Impact on IBS

The review highlights the complex role of serotonin in both gastrointestinal motility and sensitivity, as well as in affective dysregulation, revealing the intricate connections within the body, like the interconnectedness of the desert's flora and fauna. The researchers found that serotonergic modulators, like carefully targeted interventions in the desert's ecosystem, can potentially alleviate IBS symptoms, suggesting a promising avenue for treatment.

A Path to Relief: Serotonergic Modulators for IBS

The review underscores the importance of understanding the role of serotonin in IBS, like a map guiding a desert traveler through a complex landscape. The researchers emphasize that further research is needed to fully understand the intricate mechanisms of serotonin's involvement in IBS, a journey that could lead to more effective and targeted therapies.

Dr. Camel's Conclusion

This systematic review offers valuable insights into the role of serotonin in IBS, highlighting the potential of serotonergic modulators for treating this complex condition. The researchers, like seasoned desert explorers, have unearthed a promising area of research, paving the way for a more comprehensive understanding of IBS and its treatment.
Date :
  1. Date Completed 2003-04-21
  2. Date Revised 2019-09-01
Further Info :

Pubmed ID

12492731

DOI: Digital Object Identifier

10.1046/j.1365-2036.2003.01388.x

Related Literature

Article Analysis
・Effective treatment of irritable bowel syndrome
SNS
PICO Info
in preparation
Languages

English

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