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Prevention of peritoneal adhesions in the rat. The effects of dexamethasone, methylprednisolone, promethazine, and human fibrinolysin.

Author: GazzanigaA B, JamesJ M, OppenheimE B, ShobeJ B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Methylprednisolone and dexamethasone modified the number of peritoneal adhesions in rats. Promethazine was effective on its own, and the combination of methylprednisolone, promethazine, and human fibrinolysin virtually eliminated adhesion formation.
Paper Details　
Original Abstract of the Article :
Peritoneal adhesions were created in rats by brisk scrubbing of the terminal part of the ileum. Adhesions were graded by total number and the presence of small bowel obstruction. Adhesion prophylaxis was evaluated using dexamethasone, methylprednisolone sodium succinate, promethazine hydrochloride, ...See full text at original site
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引用元：
https://doi.org/10.1001/archsurg.1975.01360100071012

データ提供：米国国立医学図書館（NLM）

Preventing Peritoneal Adhesions: A Multi-faceted Approach

The field of [surgery] is constantly seeking ways to minimize complications and improve patient outcomes. This study focuses on [peritoneal adhesions], a common post-surgical complication that can lead to pain and bowel obstruction. Researchers investigated the effectiveness of various drugs in preventing [peritoneal adhesions] in rats, exploring the potential of a multi-faceted approach to this problem. Their findings suggest that a combination of [methylprednisolone], [promethazine], and [human fibrinolysin] effectively prevented [adhesion formation].

A Winning Combination for Adhesion Prevention

The study revealed that the combination of [methylprednisolone], [promethazine], and [human fibrinolysin], when administered intraperitoneally, virtually eliminated [adhesion formation] in rats. This finding suggests that a multi-drug approach can be highly effective in preventing this common surgical complication.

Implications for Health and Lifestyle

The study highlights the importance of proactive measures to prevent [peritoneal adhesions], which can have significant implications for post-surgical recovery. It encourages further research to refine and optimize these preventive strategies, potentially leading to improved patient outcomes and reduced complications.

Dr.Camel's Conclusion

This study underscores the significance of meticulous research and innovation in the field of surgery. By identifying effective combinations of drugs for preventing [peritoneal adhesions], the researchers contribute to the ongoing quest for better surgical outcomes and improved patient well-being.

Date :
  1. Date Completed 1975-10-11
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

125075

DOI: Digital Object Identifier

10.1001/archsurg.1975.01360100071012

Related Literature

Article Analysis
・Effects of promethazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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