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Clinically potential subclasses of retinoid synergists revealed by gene expression profiling.

Author: InoueKazuhide, IshidaSeiichi, KagechikaHiroyuki, OhnoYasuo, OzawaShogo, SawadaJun-Ichi, Shigemoto-MogamiYukari, ShudoKoichi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Gene expression profiling can be used to identify retinoid synergists that enhance the activity of Am80, a retinoid already in clinical trials, while potentially reducing its toxicity.
Paper Details　
Original Abstract of the Article :
Retinoids have chemopreventive and therapeutic potency in oncology and dermatology, although their application is restricted by many undesirable side effects. For the development of more effective and less toxic retinoids, gene expression analyses using DNA microarrays have the potential to suppleme...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12533672

データ提供：米国国立医学図書館（NLM）

Retinoid Synergists for Cancer and Dermatology

The realm of cancer and dermatology research is always searching for new and effective therapies. This study explores the potential of retinoids and retinoid synergists to combat these conditions. Think of these substances as powerful tools that can help us overcome the challenges of these diseases. It's like finding a hidden oasis in a vast desert—offering hope and solutions for those in need.

Retinoid Synergy

The research investigated the effects of retinoids and retinoid synergists on gene expression and cell behavior. The study found that these substances can have different effects depending on their specific properties and combinations. This is like a desert ecosystem where different plants and animals interact in specific ways to create a balanced environment. The researchers identified two subclasses of retinoid synergists, suggesting that targeted combinations of these substances might lead to more effective treatments for cancer and dermatological conditions.

Exploring New Treatment Options

The study's findings provide valuable insights into the potential of retinoids and retinoid synergists for treating cancer and skin conditions. It's like discovering a new set of tools that can help us navigate the complex and challenging terrain of these diseases. This research encourages continued exploration and investigation into these promising substances, potentially leading to new and effective therapies for those who are affected by these conditions.

Dr.Camel's Conclusion

This study emphasizes the importance of understanding the intricate interactions between different compounds in the body. Just as a camel caravan needs to adapt to the varying terrain of a desert, we can learn to leverage the power of different substances to combat disease. The researchers' findings offer a roadmap for exploring the potential of retinoids and retinoid synergists, potentially leading to more effective and personalized treatments for cancer and dermatological conditions.

Date :
  1. Date Completed 2003-10-03
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

12533672

DOI: Digital Object Identifier

12533672

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Languages

English

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