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Effect of cessation of zidovudine prophylaxis to reduce vertical transmission on maternal HIV disease progression and survival.

Author: , BardeguezArlene D, CoombsRobert, CunninghamBethann, FowlerMary Glenn, FrenkelLisa M, GandiaJorge, HuangSharon, JonesTheodore, MaupinRobert, MofensonLynne M, O'SullivanMary Jo, ShapiroDavid E, SperlingRhoda S, ZorrillaCarmen D

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study found that zidovudine monotherapy could be considered as chemoprophylaxis to reduce perinatal HIV transmission for minimally symptomatic HIV-infected pregnant women with a low viral load and normal CD4 cell count.
Paper Details　
Original Abstract of the Article :
Zidovudine prophylaxis is recommended to reduce perinatal HIV-1 transmission, but there are limited data on long-term effects on women's health. Pediatrics AIDS Clinical Trials Group (PACTG) 288 was a prospective observational study among US women randomized to zidovudine or placebo in PACTG 076 tha...See full text at original site
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引用元：
https://doi.org/10.1097/00126334-200302010-00009

データ提供：米国国立医学図書館（NLM）

Cessation of Zidovudine Prophylaxis for Vertical HIV Transmission: A Long-Term Study

Preventing mother-to-child transmission of HIV is a major public health goal. This study, like a long-term desert expedition tracking the effects of a change in the environment, investigates the long-term effects of ceasing zidovudine prophylaxis, a common treatment for reducing vertical HIV transmission, on maternal HIV disease progression and survival. The researchers conducted a prospective observational study, following women who had been randomized to receive zidovudine or placebo in a previous trial. They found that the cessation of zidovudine prophylaxis did not significantly affect maternal HIV disease progression or survival.

Long-Term Impact of Zidovudine Prophylaxis

The study's findings offer reassuring news about the long-term impact of zidovudine prophylaxis on maternal HIV disease progression and survival. The results suggest that the cessation of prophylaxis, even after years of treatment, does not significantly increase the risk of disease progression or death.

Navigating Treatment Decisions for HIV-Infected Pregnant Women

This study provides valuable information for clinicians who are making treatment decisions for HIV-infected pregnant women. The findings suggest that a careful assessment of individual patient factors, including viral load and CD4 cell count, can guide decisions about the appropriate duration of zidovudine prophylaxis.

Dr. Camel's Conclusion

This study, like a beacon of hope illuminating the path through a challenging desert, provides valuable information for clinicians and patients alike. The findings offer reassurance about the long-term safety of ceasing zidovudine prophylaxis for reducing vertical HIV transmission, while also emphasizing the importance of individualized patient care. As we continue to navigate the evolving landscape of HIV treatment, this study serves as a reminder that scientific advancements can lead to improved outcomes for both mothers and children.

Date :
  1. Date Completed 2003-03-12
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

12571527

DOI: Digital Object Identifier

10.1097/00126334-200302010-00009

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English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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