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Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins.

Author: , GyllingHelena, LindbohmNina, MiettinenTatu A, MiettinenTatu E, RajaratnamRadhakrishnan A, RelasHeikki

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

The study found that atorvastatin and simvastatin effectively reduced serum cholesterol levels in patients with coronary heart disease. Atorvastatin was more effective in reducing cholesterol precursors, while simvastatin led to an initial decrease in plant sterol concentrations. Both statins led to increases in plant sterol levels, possibly due to reduced biliary secretion and enhanced absorption.
Paper Details　
Original Abstract of the Article :
We studied changes in serum cholestanol and plant sterols (indexes of cholesterol absorption) and cholesterol precursors (indexes of cholesterol synthesis) in response to cholesterol reduction by way of 1 year's treatment with atorvastatin (n = 102) and simvastatin (n = 105) treatments in patients w...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12577049

データ提供：米国国立医学図書館（NLM）

Statins and Serum Noncholesterol Sterols: A Desert Oasis of Insights

Statins are widely used medications for lowering cholesterol levels. This study examines the effects of statins on serum noncholesterol sterols, including cholestanol, plant sterols, and cholesterol precursors, in patients with coronary heart disease. Researchers meticulously analyzed blood samples from patients who received atorvastatin or simvastatin for one year. The study found that statins significantly reduced cholesterol levels and altered the ratios of cholesterol precursors to cholesterol. It also observed changes in plant sterol concentrations, suggesting potential implications for long-term statin treatment. This research provides valuable insights into the complex interplay of cholesterol metabolism and statin therapy.

Statins: A Desert Oasis of Cholesterol Management

This study sheds light on the intricate effects of statins on cholesterol metabolism. The research, like a caravan of explorers venturing through the vast desert of cholesterol management, provides a deeper understanding of how statins impact various sterol levels. This knowledge is essential for optimizing statin therapy and minimizing potential side effects. The study highlights the importance of continued research to unravel the intricate mechanisms of cholesterol metabolism and develop more targeted and effective treatment strategies.

Navigating the Desert of Cholesterol Management: A Journey of Health

This study underscores the importance of personalized medicine in managing cholesterol levels. The research highlights the complex interplay of various sterols and emphasizes the need for ongoing research to develop optimal treatment strategies for patients with coronary heart disease. This research provides valuable insights for healthcare professionals and patients, encouraging a collaborative approach to maintaining cardiovascular health.

Dr.Camel's Conclusion

This study provides valuable insights into the effects of statins on serum noncholesterol sterols, highlighting the importance of personalized medicine and ongoing research in optimizing cholesterol management for patients with coronary heart disease.

Date :
  1. Date Completed 2003-03-07
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

12577049

DOI: Digital Object Identifier

S0022214302930222

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SNS
PICO Info
in preparation
Languages

English

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