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[Retreatment with interferon plus ribavirin in chronic hepatitis C patients with genotype 1 who had no response or a relapse with a previous interferon treatment. Long term follow-up].

Author: CalvoF, CórdobaJ, GarijoR, GobernadoM, JaénJ, LópezL, MartínezF, MolinaJ M, OlasoV, SilesM S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the effectiveness of interferon-alpha (IFN-a) plus ribavirin for treating chronic hepatitis C in patients who had either relapsed or not responded to previous interferon monotherapy. The study found that 50% of relapsing patients with genotype 1 achieved sustained remission. A 12-month treatment duration was more effective for relapsing patients than a 6-month duration, but less effective for non-responders. Sustained response was seen in 9.3% of non-responders. Overall, combining interferon with ribavirin improved liver histology in patients with sustained remission and in one-third of non-responders.
Paper Details　
Original Abstract of the Article :
The aims of this study were twofold: i) to evaluate the sustained response rate at 6 months, at 12 months and at the end of the follow-up [(46.39 +/- 9.74 months) (range: 6-60 months)] in patients with chronic hepatitis C retreated with interferon-a (IFN-a) plus ribavirin for 6 months (group A), 12 ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12582428

データ提供：米国国立医学図書館（NLM）

[Retreatment with interferon plus ribavirin in chronic hepatitis C patients with genotype 1 who had no response or a relapse with a previous interferon treatment. Long term follow-up]

Chronic hepatitis C is a serious liver infection that can lead to significant health complications. This study investigates the effectiveness of retreatment with interferon-alpha (IFN-α) plus ribavirin in patients with chronic hepatitis C genotype 1 who had previously failed or relapsed on interferon treatment. The researchers conducted a long-term follow-up study to evaluate the sustained response rate and histological changes in the liver.

Retreatment Strategies for Chronic Hepatitis C

This study provides valuable insights into retreatment strategies for chronic hepatitis C genotype 1. The researchers' findings suggest that retreatment with IFN-α plus ribavirin can achieve sustained response in a significant proportion of patients who had previously failed or relapsed on interferon monotherapy. The study also highlights the importance of long-term follow-up to assess the long-term effects of treatment.

A Hopeful Oasis in the Desert of Hepatitis C

The study's findings offer a glimmer of hope for individuals with chronic hepatitis C genotype 1 who have previously failed or relapsed on interferon treatment. The researchers' insights into the potential of retreatment with IFN-α plus ribavirin provide a valuable tool for managing this challenging condition. It's like finding a well of hope in a seemingly barren desert, offering a path towards better health outcomes.

Dr.Camel's Conclusion

This study provides valuable insights into the effectiveness of retreatment with interferon-alpha plus ribavirin in patients with chronic hepatitis C genotype 1 who had previously failed or relapsed on interferon treatment. The researchers' findings suggest that this combination therapy can achieve sustained response in a significant proportion of patients, offering a potential path towards better health outcomes. The study highlights the importance of long-term follow-up to assess the long-term effects of treatment and the ongoing need for research to develop more effective treatments for chronic hepatitis C.
Date :
  1. Date Completed 2003-09-29
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

12582428

DOI: Digital Object Identifier

12582428

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