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The effect of granisetron on in vitro metabolism of paclitaxel and docetaxel.
Author: HoshiaiHiroshi, NakajimaHiroyuki, NodaKiichiro, NozakiKoichi, WatanabeYoh
Original Abstract of the Article :
Paclitaxel and docetaxel are effective anticancer agents; however, these agents can be associated with the debilitating side effects of nausea and vomiting, thereby necessitatingthe administration of concomitant antiemetic agents. This increases the potential fordrug-drug interactionsthrough inhibit...See full text at original site
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1097/00130404-200301000-00011
データ提供：米国国立医学図書館（NLM）
Investigating the Impact of Granisetron on Paclitaxel and Docetaxel Metabolism
Paclitaxel and docetaxel, powerful anticancer drugs, can cause debilitating side effects such as nausea and vomiting. This study explores the potential for drug interactions between granisetron, a common antiemetic, and these anticancer agents. The researchers investigated the effects of granisetron on the metabolism of paclitaxel and docetaxel in human liver microsomal preparations. The results, however, are not detailed, highlighting the need for further research to fully understand the potential impact of granisetron on the metabolism and efficacy of these anticancer drugs.
Understanding Drug Interactions in Cancer Treatment
This study underscores the importance of considering potential drug interactions in cancer treatment, particularly when combining antiemetic agents with anticancer drugs. The research emphasizes the need for careful monitoring and further investigation to ensure the safe and effective use of these medications. This is a critical area of research in the vast desert of drug development and cancer therapy.
Optimizing Treatment Regimens for Cancer Patients
This research highlights the need for a comprehensive understanding of drug interactions to optimize treatment regimens for cancer patients. By understanding how different medications interact, clinicians can potentially minimize side effects and maximize treatment efficacy. This is a crucial step towards ensuring the best possible outcomes for cancer patients.
Dr.Camel's Conclusion
This study investigates the potential for drug interactions between granisetron and the anticancer drugs paclitaxel and docetaxel. While the findings are not detailed, it highlights the importance of understanding these interactions to ensure the safe and effective use of these medications in cancer treatment. This research underscores the need for continued research in this area to optimize treatment regimens and improve outcomes for cancer patients.
Date :
- Date Completed 2003-06-10
- Date Revised 2019-11-06
Further Info :
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