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Histamine-induced cytokine production and ICAM-1 expression in human conjunctival fibroblasts.

Author: De PaoliMassimo, DeFranchisGiuseppe, FregonaIva, LeonardiAndrea, PlebaniMario, SecchiAntonio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Histamine was found to have pro-inflammatory effects on conjunctival fibroblasts, inducing the production of IL-1, IL-6, and IL-8, and the expression of ICAM-1. The H1 antagonist emedastine significantly reduced cytokine and ICAM-1 expression from histamine-stimulated fibroblasts, suggesting a potential role in managing chronic allergic conjunctival diseases.
Paper Details　
Original Abstract of the Article :
PURPOSE: Conjunctival fibroblasts stimulated with histamine (H) may be directly involved in the inflammatory and remodeling processes of chronic allergic conjunctival diseases. METHODS: Proinflammatory cytokine and growth factor production, and the expression of intercellular adhesion molecule-1 (I...See full text at original site
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引用元：
https://doi.org/10.1076/ceyr.25.3.189.13479

データ提供：米国国立医学図書館（NLM）

Histamine's Effects on Conjunctival Fibroblasts: A Pro-Inflammatory Role

The world of allergies is like a vast desert landscape, where triggers can unexpectedly cause allergic reactions. This research investigates the effects of histamine, a key player in allergic reactions, on conjunctival fibroblasts, cells found in the lining of the eye.

The researchers were interested in understanding how histamine might contribute to the inflammation and remodeling process in allergic conjunctivitis, a common condition affecting the eyes. They studied the response of conjunctival fibroblasts to different concentrations of histamine, looking for clues about how histamine might be affecting the development and progression of allergy-related inflammation.

They found that histamine stimulated the production of pro-inflammatory cytokines and the expression of ICAM-1, a molecule involved in cell adhesion. These findings suggest that histamine might be playing a role in promoting inflammation in allergic conjunctivitis.

Histamine's Pro-Inflammatory Role: A Storm in the Desert of Allergies

This study provides valuable insight into the role of histamine in allergic conjunctivitis. The researchers found that histamine stimulates the production of pro-inflammatory cytokines, like a storm brewing in the desert, causing inflammation and discomfort.

Understanding the Triggers of Allergic Conjunctivitis

This study highlights the importance of understanding the triggers of allergic conjunctivitis. It's like understanding the desert winds that can trigger sandstorms. By knowing the triggers, we can better manage and prevent allergic reactions.

Dr.Camel's Conclusion

This study provides valuable insight into the role of histamine in allergic conjunctivitis. It's like understanding the desert wind that can trigger a sandstorm. The study suggests that histamine plays a role in promoting inflammation in allergic conjunctivitis, providing a valuable starting point for developing new therapies to combat this condition.

Date :
  1. Date Completed 2003-03-27
  2. Date Revised 2019-09-01
Further Info :

Pubmed ID

12607189

DOI: Digital Object Identifier

10.1076/ceyr.25.3.189.13479

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English

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