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Topical butyrate improves efficacy of 5-ASA in refractory distal ulcerative colitis: results of a multicentre trial.

Author: , AnneseV, BresciG, CaprilliR, D'IncàR, GiaccariS, IngrossoM, MansiC, RieglerG, ValpianiD, VerniaP, d'AlbasioG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study aimed to confirm the effectiveness of topical butyrate and 5-ASA in treating ulcerative colitis affecting the lower part of the colon that does not respond to standard treatments.
Paper Details　
Original Abstract of the Article :
The treatment of distal ulcerative colitis, refractory to conventional 5-ASA/steroid treatment, is still a matter of debate. The present study aimed at confirming, with adequate statistical power, previous data indicating the usefulness of topical butyrate and 5-ASA in the treatment of this conditio...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2362.2003.01130.x

データ提供：米国国立医学図書館（NLM）

Topical Butyrate: A New Oasis for Refractory Distal Ulcerative Colitis

The treatment of [refractory distal ulcerative colitis] is a complex and challenging task, like navigating a vast and unforgiving desert. This study delves into this challenging terrain, exploring the potential of [topical butyrate] in combination with [5-ASA] as a new and effective treatment approach.

Topical Butyrate: A Potential Solution for Refractory Ulcerative Colitis

This study, like a desert explorer seeking a hidden oasis, provides evidence supporting the efficacy of topical butyrate in combination with 5-ASA for refractory distal ulcerative colitis. The researchers found this combination to be [significantly beneficial] compared to conventional treatment, offering a potential solution to a challenging condition.

A New Hope for Patients with Refractory Ulcerative Colitis

This research, like a refreshing oasis in the desert, offers hope for patients suffering from refractory distal ulcerative colitis. The potential of topical butyrate in combination with 5-ASA provides a new path towards effective treatment, potentially alleviating symptoms and improving quality of life for those affected.

Dr. Camel's Conclusion

This research, like a beacon of light in the desert of inflammatory bowel disease, illuminates a promising new treatment approach for refractory distal ulcerative colitis. The combination of topical butyrate and 5-ASA has shown significant benefit, offering hope for a better quality of life for patients struggling with this debilitating condition.

Date :
  1. Date Completed 2003-07-21
  2. Date Revised 2021-04-16
Further Info :

Pubmed ID

12641543

DOI: Digital Object Identifier

10.1046/j.1365-2362.2003.01130.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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