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Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats.

Author: Jevtovic-TodorovicV, MeyenburgA P, OlneyJ W, WozniakD F

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Procyclidine and ethopropazine, when combined with an alpha(2) adrenergic agonist, effectively and long-lastingly relieved neuropathic pain in rats without neurotoxic side effects.
Paper Details　
Original Abstract of the Article :
Procyclidine and ethopropazine, widely used as anti-parkinsonian agents because of their anti-cholinergic action, are also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. In the pres...See full text at original site
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引用元：
https://doi.org/10.1016/s0028-3908(03)00069-8

データ提供：米国国立医学図書館（NLM）

Alleviating Neuropathic Pain: Finding Relief in the Desert of Chronic Pain

This research explores the potential of anti-parkinsonian agents, procyclidine and ethopropazine, in treating neuropathic pain, a debilitating condition characterized by chronic and often severe pain. The authors investigate the effects of these agents on thermal hyperalgesia in rats with sciatic nerve ligation, a model of neuropathic pain. This research is akin to searching for a soothing balm in the desert of chronic pain.

Anti-Parkinsonian Agents: A Potential Oasis for Neuropathic Pain

The study found that both procyclidine and ethopropazine effectively alleviated thermal hyperalgesia in a dose-dependent manner, offering potential relief for neuropathic pain. Moreover, the combination of these agents with an alpha(2) adrenergic agonist enhanced pain relief and minimized side effects. This finding is like discovering a hidden oasis in the desert of chronic pain, offering a source of respite and potential treatment.

Navigating the Desert of Chronic Pain: Seeking Relief and Hope

This research highlights the potential of anti-parkinsonian agents, procyclidine and ethopropazine, as therapeutic options for neuropathic pain, offering hope for individuals struggling with this debilitating condition. This study encourages further research into these agents and their potential benefits for managing chronic pain.

Dr. Camel's Conclusion

This study suggests that anti-parkinsonian agents, procyclidine and ethopropazine, may hold promise as therapeutic options for neuropathic pain, offering potential relief for those navigating the challenging terrain of chronic pain.

Date :
  1. Date Completed 2003-08-11
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

12681372

DOI: Digital Object Identifier

10.1016/s0028-3908(03)00069-8

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