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Effects of three fluoroquinolones on QT interval in healthy adults after single doses.

Author: AbelsRobert, ChienShuchean, GoodmanDaniel B, HuntThomas L, NatarajanJaya, NoelGary J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Moxifloxacin caused a greater increase in QT and QTc intervals than levofloxacin or ciprofloxacin in healthy volunteers after a single high dose. The clinical relevance of these differences is not known.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: A clinical trial was conducted in healthy adult volunteers to assess the effect of levofloxacin, moxifloxacin, and ciprofloxacin on the QT and QTc interval. METHODS: Electrocardiograms were recorded 24 hours before and after subjects took placebo, 1000 mg levofloxacin, 800 mg moxifloxaci...See full text at original site
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引用元：
https://doi.org/10.1016/s0009-9236(03)00009-2

データ提供：米国国立医学図書館（NLM）

Fluoroquinolones: Navigating the QT Interval Desert

The field of cardiology is a vast and often challenging desert, with researchers constantly seeking to understand the complex interplay of drugs and the heart. This study investigates the effects of three fluoroquinolones, levofloxacin, moxifloxacin, and ciprofloxacin, on the QT interval, a measure of electrical activity in the heart.

The QT Interval: A Delicate Balance

The study reveals that moxifloxacin has a greater effect on the QT interval than levofloxacin or ciprofloxacin. The authors caution about the potential for QT prolongation, a side effect that can lead to serious heart rhythm disturbances. It's like navigating a delicate balance between the stability of a desert oasis and the potential for a flash flood – careful monitoring and awareness are crucial.

Navigating the Heart's Rhythms

This research underscores the importance of understanding the potential impact of drugs on cardiac function. The authors highlight the need for careful assessment of the QT interval, especially in patients at risk for cardiac arrhythmias. It's like observing the flow of a desert river, recognizing both its beauty and its unpredictable nature.

Dr.Camel's Conclusion

This study emphasizes the importance of careful drug selection and monitoring to minimize the risk of QT prolongation. It's a reminder that the heart, like a desert oasis, requires careful attention and respect to maintain its delicate balance.

Date :
  1. Date Completed 2003-05-07
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

12709719

DOI: Digital Object Identifier

10.1016/s0009-9236(03)00009-2

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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