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The effectiveness and safety of hepatitis A vaccine: a systematic review.

Author: DemicheliVittorio, TibertiDonatella

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A systematic review was conducted to assess the efficacy and safety of hepatitis A vaccines in adults and children. Combined inactivated vaccine effectiveness was 86% (95% CI: 63-95%) and combined attenuated vaccine effectiveness was 95% (95% CI: 81-99%). Inactivated vaccine effectiveness in the prevention of HAV secondary cases, compared to non-intervention was 82% (95% CI: 23-96%). Safety profile of vaccines was similar to that of their comparators.
Paper Details　
Original Abstract of the Article :
We report on the conduct of a systematic review to assess the efficacy and the safety of hepatitis A vaccines in adults and children. We identified, retrieved, and assessed all trials evaluating the effects of hepatitis A vaccines on prevention of cases of hepatitis A, death from hepatitis A, and as...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
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引用元：
https://doi.org/10.1016/s0264-410x(03)00135-x

データ提供：米国国立医学図書館（NLM）

The Effectiveness and Safety of Hepatitis A Vaccine: A Systematic Review

The field of [vaccination] is crucial for public health, with [hepatitis A vaccine] playing a vital role in protecting individuals from this potentially serious infection. This systematic review assessed the [efficacy and safety] of hepatitis A vaccines in both children and adults. The review found [convincing evidence] of the effectiveness and safety of [inactivated HAV vaccines] based on data from eight randomized trials.

The Effectiveness and Safety of Hepatitis A Vaccine

The systematic review found that [inactivated hepatitis A vaccines were highly effective (86%) in preventing hepatitis A cases] and [attenuated vaccines showed even higher effectiveness (95%)]. The vaccines were also found to have [a safety profile comparable to that of their control groups].

Protecting Yourself and Your Community from Hepatitis A

Just as a desert traveler prepares for the journey by gathering essential supplies, individuals can protect themselves from hepatitis A by [getting vaccinated]. This simple step can [significantly reduce the risk of infection] and contribute to a healthier community.

Dr.Camel's Conclusion

Vaccination is a powerful tool for preventing infectious diseases. This research provides further confirmation of the [efficacy and safety] of hepatitis A vaccines, encouraging us to embrace this vital preventive measure and ensure a healthier future.

Date :
  1. Date Completed 2004-01-05
  2. Date Revised 2019-07-28
Further Info :

Pubmed ID

12744850

DOI: Digital Object Identifier

10.1016/s0264-410x(03)00135-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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