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Chronic depression and comorbid personality disorders: response to sertraline versus imipramine.

Author: HarrisonWilma M, HirschfeldRobert M A, KellerMartin B, KornsteinSusan G, McCulloughJames P, RussellJames M, SheaM Tracie

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

In patients with chronic major depression or double depression, Axis II personality disorder comorbidity is common, with 46% meeting criteria for at least one disorder and 21% meeting criteria for at least two. The presence of Axis II personality disorder comorbidity does not significantly impact treatment response or time to response with sertraline or imipramine.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Chronic subtypes of depression appear to be associated with high rates of Axis II personality disorder comorbidity. Few studies, though, have systematically examined the clinical correlates of Axis II personality disorder comorbidity or its effect on treatment response or time to respons...See full text at original site
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引用元：
https://doi.org/10.4088/jcp.v64n0510

データ提供：米国国立医学図書館（NLM）

Chronic Depression and Personality Disorders: A Look at Treatment Response

The realm of chronic depression, like a vast and often unforgiving desert, presents unique challenges for clinicians and patients alike. This study explores the impact of personality disorder comorbidity on treatment response to sertraline and imipramine, two commonly used antidepressants.

The authors, like researchers navigating a complex desert landscape, examine the relationship between Axis II personality disorders and treatment outcomes in patients with chronic major depression. They seek to understand how personality disorder comorbidity influences the effectiveness of antidepressant medication.

Personality Disorders: A Complex Factor in Depression Treatment

This study, like a beacon of insight in the desert of depression research, highlights the complexity of treating chronic depression when personality disorders are present. The findings suggest that personality disorder comorbidity may not significantly hinder treatment response, but further research is needed to fully understand its impact.

Tailored Treatment Approaches: A Key to Effective Depression Management

This research underscores the importance of tailored treatment approaches for patients with chronic depression and personality disorder comorbidity. Like a skilled desert navigator adapting to changing conditions, clinicians must consider the individual patient's needs and tailor their treatment strategy accordingly. A comprehensive approach that addresses both depression and personality disorders is essential for optimal outcomes.

Dr. Camel's Conclusion

The desert of chronic depression can be a challenging landscape to navigate, especially when personality disorders are present. This study provides valuable insights into the complexities of treatment response in this population. While personality disorder comorbidity may not significantly impede treatment outcomes, it's crucial to develop tailored approaches and provide comprehensive care for patients with chronic depression.

Date :
  1. Date Completed 2003-07-03
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

12755659

DOI: Digital Object Identifier

10.4088/jcp.v64n0510

Related Literature

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・Effective treatment of personality disorders
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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