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Combination therapy with hormone replacement and alendronate for prevention of bone loss in elderly women: a randomized controlled trial.

Author: GreenspanSusan L, ParkerRobert A, ResnickNeil M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Combination therapy with hormone replacement and alendronate is efficacious and well tolerated in elderly women with osteoporosis. Alendronate monotherapy is superior to hormone replacement therapy, and combination therapy is superior to either monotherapy.
Paper Details　
Original Abstract of the Article :
CONTEXT: Therapy with individual antiresorptive agents has been shown to be effective for prevention and treatment of postmenopausal osteoporosis, but whether combination antiresorptive therapy with hormones and bisphosphonates is safe or efficacious or how these agents compare in elderly women is u...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12759324

データ提供：米国国立医学図書館（NLM）

Bone Health in Elderly Women: A Combination Approach to Prevention

The aging process is a natural journey, much like the gradual erosion of a desert landscape over time. As women age, their bones become more susceptible to loss, increasing their risk of osteoporosis. This research investigates the potential benefits of combining hormone replacement therapy with alendronate, a bisphosphonate medication, in preventing bone loss in elderly women.

The researchers, acting as diligent desert guides, conducted a randomized controlled trial to evaluate the efficacy and safety of this combination therapy. They compared its effects to those of monotherapy with hormone replacement or alendronate alone.

The study's findings suggest that combining hormone replacement therapy with alendronate may offer a more effective approach to preventing bone loss in elderly women than either therapy alone.

Strengthening the Bones: The Power of Combination Therapy

The study's results demonstrate the potential of combining hormone replacement therapy with alendronate in preventing bone loss in elderly women. The researchers observed significant improvements in bone mineral density at various skeletal sites in women receiving combination therapy compared to those receiving monotherapy.

Navigating the Desert of Bone Health: Considerations for Individual Needs

This research highlights the importance of tailoring treatment approaches to individual needs. While the study found that combination therapy was effective, it's important to consult with a healthcare provider to determine the most appropriate treatment plan based on individual risk factors and medical history.

Dr. Camel's Conclusion

Maintaining strong bones as we age is essential, much like preserving a desert oasis amidst the harshness of time. This research suggests that combining hormone replacement therapy with alendronate may offer a more effective strategy for preventing bone loss in elderly women, providing a potential oasis of strength in their later years.

Date :
  1. Date Completed 2003-06-13
  2. Date Revised 2016-10-17
Further Info :

Pubmed ID

12759324

DOI: Digital Object Identifier

289/19/2525

Related Literature

Article Analysis
・Effective treatment of osteoporosis
SNS
PICO Info
in preparation
Languages

English

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