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Acne: comparing hormonal approaches to antibiotics and isotretinoin.

Author: JemecGregor B E, LarsenTina Holst

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review assessed the effectiveness of systemic treatments for severe acne, including antibiotics, anti-androgens, and retinoids. Isotretinoin showed the highest improvement (85% on average) compared to baseline, followed by tetracyclines (54%) and cyproterone acetate plus ethinyloestradiol (65%). Isotretinoin also seemed to reduce relapse risk. However, limitations such as potential teratogenicity restrict widespread use. Combined topical and systemic therapies offer relief, but future standardized studies are needed for better comparison and evidence-based recommendations.
Paper Details　
Original Abstract of the Article :
Acne is a common and disfiguring disease affecting a significant proportion of the general population. In milder cases topical therapy is sufficient. However, in more severe cases where papulopustular or nodulocystic acne is present, there is a need of systemic treatment. The latter include antibiot...See full text at original site
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引用元：
https://doi.org/10.1517/14656566.4.7.1097

データ提供：米国国立医学図書館（NLM）

Acne: Comparing Treatment Options for a Common Skin Condition

The world of dermatology is always seeking new and effective solutions for common skin conditions, such as acne. This study examines the efficacy of various systemic treatments for severe acne, including antibiotics, anti-androgens, and retinoids. The authors conducted a systematic review of the literature to assess the effectiveness of these medications in treating severe acne, highlighting the need for further research to standardize treatment protocols and ensure accurate comparisons between different therapies.

Isotretinoin Shows Promising Results for Severe Acne

The study revealed that isotretinoin, a retinoid medication, demonstrated the highest rate of improvement in severe acne, achieving an 85% improvement compared to baseline. While tetracyclines and cyproterone acetate plus ethinyloestradiol showed moderate improvements, they were less effective than isotretinoin. These findings suggest that isotretinoin may be a more effective treatment option for severe acne, although its use is limited due to potential teratogenicity.

Understanding the Complexities of Acne Treatment

The treatment of acne is a complex process that requires individualized approaches. This study highlights the importance of considering various treatment options based on the severity of the condition, individual patient characteristics, and potential risks and benefits of different medications. It emphasizes the need for further research to develop safer and more effective treatment options for acne.

Dr.Camel's Conclusion

The desert of acne treatment is full of diverse flora, each offering unique solutions. Isotretinoin, like a rare desert flower, shows remarkable promise for treating severe acne. However, as with any potent remedy, its use must be carefully considered. We must continue our journey to explore new and safer solutions for acne, striving to create a world where everyone can feel confident and comfortable in their own skin.

Date :
  1. Date Completed 2003-08-19
  2. Date Revised 2019-09-16
Further Info :

Pubmed ID

12831336

DOI: Digital Object Identifier

10.1517/14656566.4.7.1097

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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