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[Comparison of the effects of epsilon-aminocaproic acid and aprotinin on intra- and postoperative bleeding in heart surgery].

Author: AlbatB, BoulfroyD, RoquefeuilB, ThévenetA, Trinh-DucP, WintrebertP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This prospective study compared the effectiveness of aprotinin and epsilon-aminocaproic acid (EACA) in reducing blood loss during and after cardiac surgery with cardiopulmonary bypass. EACA, a cheaper antifibrinolytic drug, was found to be as effective as aprotinin, suggesting it may be a more cost-effective alternative.
Paper Details　
Original Abstract of the Article :
Excessive bleeding during and after cardiac surgery with cardiopulmonary bypass is a real problem in this kind of surgery. The use of prophylactic high doses of aprotinin (APROT) reduces blood loss in this context but this treatment is expensive. Some investigators have advocated that epsilon-aminoc...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1283661

データ提供：米国国立医学図書館（NLM）

Bleeding Control in Heart Surgery: A Comparison of Epsilon-Aminocaproic Acid and Aprotinin

Cardiac surgery is a complex and often challenging procedure, with excessive bleeding posing a significant risk. This study delves into the realm of bleeding management in cardiac surgery, comparing the effectiveness of two antifibrinolytic drugs: epsilon-aminocaproic acid (EACA) and aprotinin (APROT). The researchers conducted a prospective randomized study to evaluate the impact of each drug on intra- and postoperative bleeding in patients undergoing elective heart surgery. They found that EACA was as effective as APROT in reducing blood loss during and after surgery, while offering the advantage of being significantly more cost-effective.

EACA: A Cost-Effective Alternative for Bleeding Control

The study’s findings suggest that EACA is a viable and cost-effective alternative to APROT for bleeding control in cardiac surgery. The research highlights the potential of EACA to reduce blood loss without compromising patient safety or efficacy, offering a more affordable option for managing this important surgical complication.

Optimizing Cardiac Surgery: A Focus on Bleeding Management

This research provides valuable insights into the management of bleeding in cardiac surgery, highlighting the potential of EACA as a cost-effective alternative to APROT. The study’s findings underscore the importance of considering cost-effective treatment options without compromising patient care and safety.

Dr. Camel's Conclusion

Cardiac surgery is a delicate procedure, like navigating a treacherous desert path. This study, like a wise camel guide, highlights the effectiveness of EACA as a cost-effective alternative to APROT for controlling bleeding during and after surgery. The research emphasizes the importance of considering affordable options for managing surgical complications, ensuring that patients receive the best possible care.

Date :
  1. Date Completed 1993-03-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1283661

DOI: Digital Object Identifier

1283661

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in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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