Paper Details

  1. Home
  2. Paper Details

Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2'-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice.

Author: GołabJakub, JakóbisiakMarek, KamińskiRafal, KozarKatarzyna, LasekWitold, MachajEugeniusz, MackiewiczAndrzej, OłdakTomasz, SwitajTomasz, WysockiPiotr J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the efficacy of low-dose 5-aza-2'-deoxycitydine (DAC), a methylation inhibitor, in combination with interleukin (IL) 12, a potent cytokine, for cancer treatment.
Paper Details　
Original Abstract of the Article :
Recent findings indicating that many genes related to cancer development are silenced by an aberrant DNA methylation suggest that inhibitors of this process may be effective cancer therapeutics. In this study we investigated the efficacy of low-dose 5-aza-2'-deoxycitydine (DAC), a methylation inhibi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/12912964

データ提供：米国国立医学図書館（NLM）

Immunotherapy and Methylation Inhibitors: A Novel Approach to Leukemia and Melanoma

This study explores the potential of combining low-dose 5-aza-2'-deoxycytidine (DAC), a methylation inhibitor, with interleukin-12 (IL-12), a potent immune-stimulating cytokine, in treating leukemia and melanoma. The researchers investigated the synergistic antitumor effects of this combination therapy in mouse models.

Combined Therapy: Enhancing Antitumor Effectiveness

The study found that combining low-dose DAC with IL-12 significantly enhanced the antitumor effectiveness in mouse models of leukemia and melanoma. This research suggests that this combined approach could be a promising strategy for treating these cancers.

Fighting Cancer: A Multi-pronged Approach

This study highlights the importance of developing multi-pronged approaches to cancer treatment. By targeting both epigenetic mechanisms (DNA methylation) and the immune system, researchers aim to develop more effective and personalized therapies for cancer patients.

Dr.Camel's Conclusion

The battle against cancer is a long and arduous journey through a vast desert of disease. This study offers a glimpse of a promising oasis, exploring the potential of combining immunotherapy with methylation inhibitors to enhance antitumor effects and offer hope for a brighter future for cancer patients.

Date :
  1. Date Completed 2004-06-10
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

12912964

DOI: Digital Object Identifier

12912964

Related Literature

Article Analysis
・Effects of decitabine injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.